Atomic structure of the human cytomegalovirus capsid with its securing tegument layer of pp150-Reference-Cited by-同舟云学术

Atomic structure of the human cytomegalovirus capsid with its securing tegument layer of pp150

Published:2017-06-30 Issue:6345 Volume:356 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Yu Xuekui¹²^ORCID,Jih Jonathan¹²^ORCID,Jiang Jiansen²,Zhou Z. Hong¹²^ORCID

Affiliation:

1. Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095-7364, USA.

2. California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095-7364, USA.

Abstract

Strong under pressure Human cytomegalovirus (HCMV) is a member of the herpesvirus family that can cause life-threatening infections in those who are immunocompromised. HCMV encodes a genome that is about 50% larger than that of herpes simplex virus 1 (the virus that causes cold sores), but these two viruses have similar-sized capsids. Yu et al. used cryo–electron microscopy to determine the structure of the HCMV capsid to 3.9-Å resolution. This is the first high-resolution capsid structure from the herpesvirus family. It reveals extensive interactions that stabilize the capsid to withstand the high pressure that comes from accommodating such a large genome. Science , this issue p. eaam6892

Funder

National Science Foundation

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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