Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms-Reference-Cited by-同舟云学术

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

Published:2020-12-04 Issue:6521 Volume:370 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Gordon David E.¹²³⁴^ORCID,Hiatt Joseph¹⁴⁵⁶⁷^ORCID,Bouhaddou Mehdi¹²³⁴^ORCID,Rezelj Veronica V.⁸^ORCID,Ulferts Svenja⁹^ORCID,Braberg Hannes¹²³⁴^ORCID,Jureka Alexander S.¹⁰^ORCID,Obernier Kirsten¹²³⁴^ORCID,Guo Jeffrey Z.¹²³⁴^ORCID,Batra Jyoti¹²³⁴^ORCID,Kaake Robyn M.¹²³⁴^ORCID,Weckstein Andrew R.¹¹^ORCID,Owens Tristan W.¹²^ORCID,Gupta Meghna¹²^ORCID,Pourmal Sergei¹²^ORCID,Titus Erron W.¹²^ORCID,Cakir Merve¹²³⁴^ORCID,Soucheray Margaret¹²³⁴^ORCID,McGregor Michael¹²³⁴^ORCID,Cakir Zeynep¹²³⁴,Jang Gwendolyn¹²³⁴^ORCID,O’Meara Matthew J.¹³^ORCID,Tummino Tia A.¹²¹⁴^ORCID,Zhang Ziyang¹²³¹⁵^ORCID,Foussard Helene¹²³⁴^ORCID,Rojc Ajda¹²³⁴^ORCID,Zhou Yuan¹²³⁴^ORCID,Kuchenov Dmitry¹²³⁴,Hüttenhain Ruth¹²³⁴^ORCID,Xu Jiewei¹²³⁴^ORCID,Eckhardt Manon¹²³⁴^ORCID,Swaney Danielle L.¹²³⁴^ORCID,Fabius Jacqueline M.¹²,Ummadi Manisha¹²³⁴,Tutuncuoglu Beril¹²³⁴^ORCID,Rathore Ujjwal¹²³⁴^ORCID,Modak Maya¹²³⁴^ORCID,Haas Paige¹²³⁴^ORCID,Haas Kelsey M.¹²³⁴^ORCID,Naing Zun Zar Chi¹²³⁴^ORCID,Pulido Ernst H.¹²³⁴^ORCID,Shi Ying¹²³¹⁵,Barrio-Hernandez Inigo¹⁶^ORCID,Memon Danish¹⁶,Petsalaki Eirini¹⁶^ORCID,Dunham Alistair¹⁶^ORCID,Marrero Miguel Correa¹⁶^ORCID,Burke David¹⁶^ORCID,Koh Cassandra⁸^ORCID,Vallet Thomas⁸^ORCID,Silvas Jesus A.¹⁰^ORCID,Azumaya Caleigh M.¹²^ORCID,Billesbølle Christian¹²^ORCID,Brilot Axel F.¹²^ORCID,Campbell Melody G.¹²¹⁷^ORCID,Diallo Amy¹²^ORCID,Dickinson Miles Sasha¹²^ORCID,Diwanji Devan¹²^ORCID,Herrera Nadia¹²,Hoppe Nick¹²^ORCID,Kratochvil Huong T.¹²^ORCID,Liu Yanxin¹²^ORCID,Merz Gregory E.¹²^ORCID,Moritz Michelle¹²^ORCID,Nguyen Henry C.¹²^ORCID,Nowotny Carlos¹²^ORCID,Puchades Cristina¹²^ORCID,Rizo Alexandrea N.¹²^ORCID,Schulze-Gahmen Ursula¹²^ORCID,Smith Amber M.¹²^ORCID,Sun Ming¹²¹⁸^ORCID,Young Iris D.¹²^ORCID,Zhao Jianhua¹²^ORCID,Asarnow Daniel¹²,Biel Justin¹²^ORCID,Bowen Alisa¹²^ORCID,Braxton Julian R.¹²^ORCID,Chen Jen¹²,Chio Cynthia M.¹²^ORCID,Chio Un Seng¹²^ORCID,Deshpande Ishan¹²^ORCID,Doan Loan¹²,Faust Bryan¹²^ORCID,Flores Sebastian¹²^ORCID,Jin Mingliang¹²^ORCID,Kim Kate¹²^ORCID,Lam Victor L.¹²,Li Fei¹²^ORCID,Li Junrui¹²^ORCID,Li Yen-Li¹²^ORCID,Li Yang¹²^ORCID,Liu Xi¹²^ORCID,Lo Megan¹²^ORCID,Lopez Kyle E.¹²,Melo Arthur A.¹²^ORCID,Moss Frank R.¹²^ORCID,Nguyen Phuong¹²,Paulino Joana¹²^ORCID,Pawar Komal Ishwar¹²^ORCID,Peters Jessica K.¹²^ORCID,Pospiech Thomas H.¹²^ORCID,Safari Maliheh¹²^ORCID,Sangwan Smriti¹²^ORCID,Schaefer Kaitlin¹²,Thomas Paul V.¹²^ORCID,Thwin Aye C.¹²^ORCID,Trenker Raphael¹²^ORCID,Tse Eric¹²^ORCID,Tsui Tsz Kin Martin¹²^ORCID,Wang Feng¹²^ORCID,Whitis Natalie¹²^ORCID,Yu Zanlin¹²^ORCID,Zhang Kaihua¹²^ORCID,Zhang Yang¹²^ORCID,Zhou Fengbo¹²,Saltzberg Daniel¹²¹⁹^ORCID,Hodder Anthony J.²⁰^ORCID,Shun-Shion Amber S.²⁰^ORCID,Williams Daniel M.²⁰^ORCID,White Kris M.²¹²²^ORCID,Rosales Romel²¹²²^ORCID,Kehrer Thomas²¹²²^ORCID,Miorin Lisa²¹²²^ORCID,Moreno Elena²¹²²^ORCID,Patel Arvind H.²³^ORCID,Rihn Suzannah²³^ORCID,Khalid Mir M.⁴^ORCID,Vallejo-Gracia Albert⁴^ORCID,Fozouni Parinaz⁴⁵⁷^ORCID,Simoneau Camille R.⁴⁷^ORCID,Roth Theodore L.⁵⁶⁷,Wu David⁵⁷,Karim Mohd Anisul²⁴²⁵,Ghoussaini Maya²⁴²⁵^ORCID,Dunham Ian¹⁶²⁵^ORCID,Berardi Francesco²⁶,Weigang Sebastian²⁷^ORCID,Chazal Maxime²⁸^ORCID,Park Jisoo²⁹^ORCID,Logue James³⁰^ORCID,McGrath Marisa³⁰^ORCID,Weston Stuart³⁰^ORCID,Haupt Robert³⁰^ORCID,Hastie C. James³¹^ORCID,Elliott Matthew³¹^ORCID,Brown Fiona³¹^ORCID,Burness Kerry A.³¹^ORCID,Reid Elaine³¹^ORCID,Dorward Mark³¹^ORCID,Johnson Clare³¹,Wilkinson Stuart G.³¹^ORCID,Geyer Anna³¹^ORCID,Giesel Daniel M.³¹^ORCID,Baillie Carla³¹,Raggett Samantha³¹^ORCID,Leech Hannah³¹^ORCID,Toth Rachel³¹,Goodman Nicola³¹^ORCID,Keough Kathleen C.⁴^ORCID,Lind Abigail L.⁴^ORCID,Klesh Reyna J.³²^ORCID,Hemphill Kafi R.³³^ORCID,Carlson-Stevermer Jared³⁴^ORCID,Oki Jennifer³⁴^ORCID,Holden Kevin³⁴^ORCID,Maures Travis³⁴,Pollard Katherine S.⁴³⁵³⁶^ORCID,Sali Andrej¹²¹⁴¹⁹^ORCID,Agard David A.¹²¹²³⁷^ORCID,Cheng Yifan¹²¹²¹⁵³⁷^ORCID,Fraser James S.¹²¹²¹⁹^ORCID,Frost Adam¹²¹²³⁷^ORCID,Jura Natalia¹²³¹²³⁸^ORCID,Kortemme Tanja¹²¹²¹⁹³⁹^ORCID,Manglik Aashish¹²¹²¹⁴^ORCID,Southworth Daniel R.¹¹²³⁷,Stroud Robert M.¹²¹²³⁷^ORCID,Alessi Dario R.³¹^ORCID,Davies Paul³¹^ORCID,Frieman Matthew B.³⁰^ORCID,Ideker Trey²⁹⁴⁰^ORCID,Abate Carmen²⁶,Jouvenet Nolwenn²⁷²⁸^ORCID,Kochs Georg²⁷^ORCID,Shoichet Brian¹²¹⁴^ORCID,Ott Melanie⁴⁴¹^ORCID,Palmarini Massimo²³^ORCID,Shokat Kevan M.¹²³¹⁵^ORCID,García-Sastre Adolfo²¹²²⁴²⁴³^ORCID,Rassen Jeremy A.¹¹^ORCID,Grosse Robert⁹⁴⁴,Rosenberg Oren S.¹²¹²³⁶³⁷^ORCID,Verba Kliment A.¹²¹²¹⁴^ORCID,Basler Christopher F.¹⁰^ORCID,Vignuzzi Marco⁸^ORCID,Peden Andrew A.²⁰^ORCID,Beltrao Pedro¹⁶^ORCID,Krogan Nevan J.¹²³⁴²¹^ORCID,Owens Tristan W.,Gupta Meghna,Pourmal Sergei,Titus Erron W.,Azumaya Caleigh M.,Billesbølle Christian,Brilot Axel F.,Campbell Melody G.,Diallo Amy,Dickinson Miles Sasha,Diwanji Devan,Herrera Nadia,Hoppe Nick,Kratochvil Huong T.,Liu Yanxin,Merz Gregory E.,Moritz Michelle,Nguyen Henry C.,Nowotny Carlos,Puchades Cristina,Rizo Alexandrea N.,Schulze-Gahmen Ursula,Smith Amber M.,Sun Ming,Young Iris D.,Zhao Jianhua,Asarnow Daniel,Biel Justin,Bowen Alisa,Braxton Julian R.,Chen Jen,Chio Cynthia M.,Chio Un Seng,Deshpande Ishan,Doan Loan,Faust Bryan,Flores Sebastian,Jin Mingliang,Kim Kate,Lam Victor L.,Li Fei,Li Junrui,Li Yen-Li,Li Yang,Liu Xi,Lo Megan,Lopez Kyle E.,Melo Arthur A.,Moss Frank R.,Nguyen Phuong,Paulino Joana,Pawar Komal Ishwar,Peters Jessica K.,Pospiech Thomas H.,Safari Maliheh,Sangwan Smriti,Schaefer Kaitlin,Thomas Paul V.,Thwin Aye C.,Trenker Raphael,Tse Eric,Tsui Tsz Kin Martin,Wang Feng,Whitis Natalie,Yu Zanlin,Zhang Kaihua,Zhang Yang,Zhou Fengbo,Trinidad Donovan,Agard David A.,Cheng Yifan,Fraser James S.,Frost Adam,Jura Natalia,Kortemme Tanja,Manglik Aashish,Southworth Daniel R.,Stroud Robert M.,Rosenberg Oren S.,Verba Kliment A.,Damas Joana,Hughes Graham M.,Keough Kathleen C.,Painter Corrie A.,Persky Nicole S.,Corbo Marco,Kirilenko Bodgan,Hiller Michael,Koepfli Klaus-Peter,Kaplow Irene,Wirthlin Morgan,Pfenning Andreas R.,Zhao Huabin,Genereux Diane P.,Swofford Ross,Lind Abigail,Pollard Katherine S.,Ryderq Oliver A.,Nweeia Martin T.,Meadows Jennifer,Dong Michael,Wallerman Ola,Marinescu Vikki,Lindblad-Toh Kerstin,Ray David A.,Power Sarahjane,Teeling Emma C.,Chauhan Gaurav,Li Shirley Xue,Karlsson Elinor K.,Lewin Harris A., ,

Affiliation:

1. Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.

2. QBI, University of California, San Francisco, CA 94158, USA.

3. Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.

4. J. David Gladstone Institutes, San Francisco, CA 94158, USA.

5. Medical Scientist Training Program, University of California, San Francisco, CA 94143, USA.

6. Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA.

7. Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143, USA.

8. Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724, Paris, cedex 15, France.

9. Institute for Clinical and Experimental Pharmacology and Toxicology I, University of Freiburg, 79104 Freiburg, Germany.

10. Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.

11. Aetion, Inc., New York, NY 10001, USA.

12. QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.

13. Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.

14. Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA.

15. Howard Hughes Medical Institute, San Francisco, CA 94158, USA.

16. European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.

17. Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

18. Beam Therapeutics, Cambridge, MA 02139, USA.

19. Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA.

20. Department of Biomedical Science, Centre for Membrane Interactions and Dynamics, University of Sheffield, Firth Court, Sheffield S10 2TN, UK.

21. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

22. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

23. MRC–University of Glasgow Centre for Virus Research, Glasgow G61 1QH, Scotland, UK.

24. Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.

25. Open Targets, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.

26. Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari ‘ALDO MORO’, Via Orabona, 4 70125, Bari, Italy.

27. Institute of Virology, Medical Center–University of Freiburg, 79104 Freiburg, Germany.

28. Département de Virologie, CNRS UMR 3569, Institut Pasteur, Paris 75015, France.

29. Department of Medicine, University of California, San Diego, CA 92093, USA.

30. Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

31. MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

32. HealthVerity, Philadelphia, PA 19103, USA.

33. Department of Neurology, University of California, San Francisco, CA 94143, USA.

34. Synthego Corporation, Redwood City, CA 94063, USA.

35. Department of Epidemiology & Biostatistics, University of California, San Francisco, CA 94158, USA.

36. Chan-Zuckerberg Biohub, San Francisco, CA 94158, USA.

37. Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA.

38. Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA.

39. The University of California, Berkeley–University of California, San Francisco Graduate Program in Bioengineering, University of California, San Francisco, CA 94158, USA.

40. Department to Bioengineering, University of California, San Diego, CA 92093, USA.

41. Department of Medicine, University of California, San Francisco, CA 94143, USA.

42. Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

43. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

44. Centre for Integrative Biological Signaling Studies (CIBSS), University of Freiburg, 79104 Freiburg, Germany.

Abstract

How lethal coronaviruses engage hosts Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is closely related to the deadly coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Considerable efforts are focused on developing treatments, and therapies that work across coronaviruses would be particularly valuable. Shedding light on the host factors hijacked by the viruses, Gordon et al. mapped the interactions between viral and human proteins for SARS-CoV-2, SARS-CoV-1, and MERS-CoV; analyzed the localization of viral proteins in human cells; and used genetic screening to identify host factors that either enhance or inhibit viral infection. For a subset of the interactions essential for the virus life cycle, the authors determined the cryo–electron microscopy structures and mined patient data to understand how targeting host factors may be relevant to clinical outcomes. Science , this issue p. eabe9403

Funder

National Science Foundation

National Institutes of Health

National Institute of Allergy and Infectious Diseases

National Human Genome Research Institute

Howard Hughes Medical Institute

NIH Office of the Director

U.S. Department of Defense

National Institute of General Medical Sciences

Chan Zuckerberg Initiative

LABoratoires d’EXcellence ARCANE

Biomedical Advanced Research and Development Authority