Broken detailed balance at mesoscopic scales in active biological systems-Reference-Cited by-同舟云学术

Broken detailed balance at mesoscopic scales in active biological systems

Published:2016-04-29 Issue:6285 Volume:352 Page:604-607
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Battle Christopher¹²,Broedersz Chase P.²³⁴,Fakhri Nikta¹²⁵,Geyer Veikko F.⁶,Howard Jonathon⁶,Schmidt Christoph F.¹²,MacKintosh Fred C.²⁷

Affiliation:

1. Drittes Physikalisches Institut, Georg-August-Universität, 37077 Göttingen, Germany.

2. The Kavli Institute for Theoretical Physics, University of California, Santa Barbara, CA 93106, USA.

3. Arnold-Sommerfeld-Center for Theoretical Physics and Center for NanoScience, Ludwig-Maximilians-Universität München, Theresienstrasse 37, D-80333 München, Germany.

4. Lewis–Sigler Institute for Integrative Genomics and Joseph Henry Laboratories of Physics, Princeton University, Princeton, NJ 08544, USA.

5. Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

6. Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.

7. Department of Physics and Astronomy, Vrije Universiteit, Amsterdam, Netherlands.

Abstract

Identifying nonequilibrium dynamics Living systems clearly operate out of thermodynamic equilibrium at the molecular scale. How these activities are manifest at the cellular scale, however, has been unclear. Battle et al. use video microscopy together with statistical thermodynamics to unambiguously identify which random fluctuations at the cellular scale are out of equilibrium (see the Perspective by Rupprecht and Prost). Transitions between states obey a detailed balance in equilibrium, whereas imbalanced transitions point to nonequilibrium dynamics. For instance, nonequilibrium dynamics can be identified in the periodic beating of a flagellum and in the nonperiodic fluctuations of primary cilia. Science , this issue p. 604 ; see also p. 514

Funder

Lewis-Sigler fellowship

German Excellence Initiative

Cluster of Excellence

Deutsche Forschungsgemeinschaft (DFG)

Human Frontier Science Program Fellowship

European Research Council

Foundation for Fundamental Research on Matter

NSF

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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