Mitochondrial Network Size Scaling in Budding Yeast

Author:

Rafelski Susanne M.12,Viana Matheus P.3,Zhang Yi14,Chan Yee-Hung M.12,Thorn Kurt S.1,Yam Phoebe5,Fung Jennifer C.5,Li Hao12,Costa Luciano da F.3,Marshall Wallace F.12

Affiliation:

1. Department of Biochemistry and Biophysics, University of California–San Francisco (UCSF), San Francisco, CA, USA.

2. Center for Systems and Synthetic Biology, UCSF, San Francisco, CA, USA.

3. Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos, SP, Brazil.

4. Center for Theoretical Biology and School of Physics, Peking University, Beijing, China.

5. Department of Obstetrics, Gynecology, and Reproductive Sciences, UCSF, San Francisco, CA, USA.

Abstract

Bud, This Mitochondrion's for You How is organelle size adjusted to be appropriate for cell size? Rafelski et al. (p. 822 ) used a quantitative method for measuring mitochondria in living budding yeast cells and found that rather than using the apparently simplest mechanism of dividing the organelles equally among the mother and daughter cells, the cells adjusted the mitochondrial level in the bud, independent of the mother's own mitochondrial content, size, or age.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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