Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing-Reference-Cited by-同舟云学术

Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing

Published:2014-02-21 Issue:6173 Volume:343 Page:885-888
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Martino Mikaël M.¹²,Briquez Priscilla S.¹,Güç Esra¹,Tortelli Federico¹,Kilarski Witold W.¹,Metzger Stephanie¹,Rice Jeffrey J.¹³,Kuhn Gisela A.⁴,Müller Ralph⁴,Swartz Melody A.¹⁵⁶,Hubbell Jeffrey A.¹⁶

Affiliation:

1. Institute of Bioengineering, School of Life Sciences and School of Engineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

2. World Premier International Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.

3. Department of Chemical Engineering, Tennessee Technological University, Cookeville, TN, USA.

4. Institute for Biomechanics, ETH Zurich, CH-8093 Zurich, Switzerland.

5. Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

6. Institute of Chemical Sciences and Engineering, School of Basic Sciences, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

Abstract

Toward Successful Tissue Repair The therapeutic use of growth factors in tissue regeneration has suffered from safety and efficacy issues. Reasoning that the unmet potential may be because of nonphysiological delivery, Martino et al. (p. 885 ) engineered growth factors to bind strongly to extracellular matrix proteins. These variants were able to induce superior tissue repair, compared to the wild-type proteins. Furthermore, unwanted side effects were decreased: For example, the engineered angiogenic growth factor VEGF showed reduced vascular permeability, a concern that has limited the therapeutic efficacy of wild-type VEGF.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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