CKAMP44: A Brain-Specific Protein Attenuating Short-Term Synaptic Plasticity in the Dentate Gyrus-Reference-Cited by-同舟云学术

CKAMP44: A Brain-Specific Protein Attenuating Short-Term Synaptic Plasticity in the Dentate Gyrus

Published:2010-03-19 Issue:5972 Volume:327 Page:1518-1522
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

von Engelhardt Jakob¹,Mack Volker¹²,Sprengel Rolf³,Kavenstock Netta⁴,Li Ka Wan²,Stern-Bach Yael⁴,Smit August B.²,Seeburg Peter H.³,Monyer Hannah¹

Affiliation:

1. Department of Clinical Neurobiology, University of Heidelberg, 6910 Heidelberg, Germany.

2. Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit, 1081 HV Amsterdam, the Netherlands.

3. Department of Molecular Neurobiology, Max Planck Institute for Medical Research, 69120 Heidelberg, Germany.

4. Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel-Canada (IMRIC), the Hebrew University–Hadassah Medical School, Jerusalem 91120, Israel.

Abstract

Dancing with AMPARs A type of transmembrane receptor for glutamate, known as AMPAR, mediates most of the fast excitatory transmission in the mammalian central nervous system. Their function is regulated by the composition of their subunits, posttranslational modifications, and protein-protein interactions. Recently, several proteins that interact with AMPARs have been identified that affect their subcellular localization, synaptic stabilization, and kinetics. Using proteomic analysis, immunohistochemistry, and electrophysiology, von Engelhardt et al. (p. 1518 , published online 25 February; see the Perspective by

Farrant and Cull-Candy

) identified a protein, CKAMP44, which modulates postsynaptic AMPA receptor gating, deactivation, and desentization.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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