Whole-brain spatial organization of hippocampal single-neuron projectomes-Reference-Cited by-同舟云学术

Whole-brain spatial organization of hippocampal single-neuron projectomes

Published:2024-02-02 Issue:6682 Volume:383 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Qiu Shou¹²^ORCID,Hu Yachuang¹²^ORCID,Huang Yiming¹³⁴^ORCID,Gao Taosha¹^ORCID,Wang Xiaofei¹^ORCID,Wang Danying¹,Ren Biyu¹^ORCID,Shi Xiaoxue¹,Chen Yu¹,Wang Xinran¹,Wang Dan¹,Han Luyao¹,Liang Yikai¹,Liu Dechen¹,Liu Qingxu¹,Deng Li¹,Chen Zhaoqin¹^ORCID,Zhan Lijie¹^ORCID,Chen Tianzhi¹,Huang Yuzhe¹³⁴^ORCID,Wu Qingge¹²^ORCID,Xie Taorong¹,Qian Liuqin¹,Jin Chenxi¹,Huang Jiawen¹,Deng Wei¹,Jiang Tao⁵^ORCID,Li Xiangning⁵⁶^ORCID,Jia Xueyan⁵^ORCID,Yuan Jing⁵^ORCID,Li Anan⁵^ORCID,Yan Jun¹²^ORCID,Xu Ninglong¹²^ORCID,Xu Lin⁷^ORCID,Luo Qingming⁶^ORCID,Poo Mu-Ming¹⁸^ORCID,Sun Yidi¹²^ORCID,Li Chengyu T.¹³^ORCID,Yao Haishan¹^ORCID,Gong Hui⁵^ORCID,Sun Yan-Gang¹²^ORCID,Xu Chun¹²^ORCID

Affiliation:

1. Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China.

2. University of the Chinese Academy of Sciences, Beijing 100049, China.

3. Lingang Laboratory, Shanghai 200031, China.

4. School of Life Sciences and Technology, ShanghaiTech University, Shanghai 201210, China.

5. HUST-Suzhou Institute for Brainsmatics, JITRI, Suzhou 215123, China.

6. State Key Laboratory of Digital Medical Engineering, Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Haikou 570228, China.

7. Key Laboratory of Animal Models and Human Disease Mechanisms, and Laboratory of learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.

8. Shanghai Center for Brain Science and Brain-Inspired Technology, Shanghai 201210, China.

Abstract

Mapping single-neuron projections is essential for understanding brain-wide connectivity and diverse functions of the hippocampus (HIP). Here, we reconstructed 10,100 single-neuron projectomes of mouse HIP and classified 43 projectome subtypes with distinct projection patterns. The number of projection targets and axon-tip distribution depended on the soma location along HIP longitudinal and transverse axes. Many projectome subtypes were enriched in specific HIP subdomains defined by spatial transcriptomic profiles. Furthermore, we delineated comprehensive wiring diagrams for HIP neurons projecting exclusively within the HIP formation (HPF) and for those projecting to both intra- and extra-HPF targets. Bihemispheric projecting neurons generally projected to one pair of homologous targets with ipsilateral preference. These organization principles of single-neuron projectomes provide a structural basis for understanding the function of HIP neurons.

Publisher

American Association for the Advancement of Science (AAAS)

Link

https://www.science.org/doi/pdf/10.1126/science.adj9198

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