Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene

Author:

Caspi Avshalom1,Sugden Karen1,Moffitt Terrie E.1,Taylor Alan1,Craig Ian W.1,Harrington HonaLee1,McClay Joseph1,Mill Jonathan1,Martin Judy1,Braithwaite Antony1,Poulton Richie1

Affiliation:

1. Medical Research Council Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College London, PO80 De Crespigny Park, London, SE5 8AF, UK. Department of Psychology, University of Wisconsin, Madison, WI 53706, USA. Dunedin School of Medicine, Department of Pathology, University of Otago, Dunedin, New Zealand.

Abstract

In a prospective-longitudinal study of a representative birth cohort, we tested why stressful experiences lead to depression in some people but not in others. A functional polymorphism in the promoter region of the serotonin transporter (5-HT T) gene was found to moderate the influence of stressful life events on depression. Individuals with one or two copies of the short allele of the 5-HT T promoter polymorphism exhibited more depressive symptoms, diagnosable depression, and suicidality in relation to stressful life events than individuals homozygous for the long allele. This epidemiological study thus provides evidence of a gene-by-environment interaction, in which an individual's response to environmental insults is moderated by his or her genetic makeup.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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