Hebbian instruction of axonal connectivity by endogenous correlated spontaneous activity

Author:

Matsumoto Naoyuki12ORCID,Barson Daniel1ORCID,Liang Liang123ORCID,Crair Michael C.1234ORCID

Affiliation:

1. Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA.

2. Kavli Institute for Neuroscience, Yale University, New Haven, CT 06510, USA.

3. Wu Tsai Institute, Yale University, New Haven, CT 06510, USA.

4. Department of Ophthalmology & Visual Science, Yale University School of Medicine, New Haven, CT 06510, USA.

Abstract

Spontaneous activity refines neural connectivity prior to the onset of sensory experience, but it remains unclear how such activity instructs axonal connectivity with subcellular precision. We simultaneously measured spontaneous retinal waves and the activity of individual retinocollicular axons and tracked morphological changes in axonal arbors across hours in vivo in neonatal mice. We demonstrate that the correlation of an axon branch’s activity with neighboring axons or postsynaptic neurons predicts whether the branch will be added, stabilized, or eliminated. Desynchronizing individual axons from their local networks, changing the pattern of correlated activity, or blocking N -methyl- d -aspartate receptors all significantly altered single-axon morphology. These observations provide the first direct evidence in vivo that endogenous patterns of correlated neuronal activity instruct fine-scale refinement of axonal processes.

Publisher

American Association for the Advancement of Science (AAAS)

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