1. Howard Hughes Medical Institute and Markey Center for Cell Signaling, Departments of Medicine and Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.
2. Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA.
3. Advanced Bioscience Laboratories Inc. Basic Research Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702, USA..