Developmental Progression to Infectivity in Trypanosoma brucei Triggered by an RNA-Binding Protein-Reference-Cited by-同舟云学术

Developmental Progression to Infectivity in Trypanosoma brucei Triggered by an RNA-Binding Protein

Published:2012-12-07 Issue:6112 Volume:338 Page:1352-1353
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kolev Nikolay G.¹,Ramey-Butler Kiantra²,Cross George A. M.³,Ullu Elisabetta²⁴,Tschudi Christian¹

Affiliation:

1. Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06536, USA.

2. Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06536, USA.

3. Laboratory of Molecular Parasitology, The Rockefeller University, New York, NY 10065, USA.

4. Department of Cell Biology, Yale School of Medicine, New Haven, CT 06536, USA.

Abstract

Awakening a Life Cycle Sleeping sickness continues to afflict populations in sub-Saharan Africa, but for the past 100 years, research on the Trypanosoma brucei protozoan parasite has been hampered by an inaccessibility of the insect vector stages to modern research tools. Kolev et al. (p. 1352 ) have identified an RNA-binding protein (RBP6) as a master regulator that drives the entire developmental program of the trypanosome through all its life-cycle stages. The ability to perform this transformation in vitro will allow study of the many biochemical and morphological changes as parasites change from dividing noninfectious forms to infectious nondividing antigenically variable forms.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference10 articles.

1. The heart of darkness: growth and form of Trypanosoma brucei in the tsetse fly

2. The development of trypanosoma gambiense in glossina palpalis

3. Expression of the RNA recognition motif protein RBP10 promotes a bloodstream-form transcript pattern in Trypanosoma brucei

4. DEVELOPMENTAL CYCLES AND BIOLOGY OF PATHOGENIC TRYPANOSOMES

5. A new asymmetric division contributes to the continuous production of infective trypanosomes in the tsetse fly

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