Cortical layer–specific critical dynamics triggering perception-Reference-Cited by-同舟云学术

Cortical layer–specific critical dynamics triggering perception

Published:2019-08-09 Issue:6453 Volume:365 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Marshel James H.¹^ORCID,Kim Yoon Seok²^ORCID,Machado Timothy A.¹²^ORCID,Quirin Sean¹^ORCID,Benson Brandon³^ORCID,Kadmon Jonathan³^ORCID,Raja Cephra²,Chibukhchyan Adelaida²^ORCID,Ramakrishnan Charu²^ORCID,Inoue Masatoshi²^ORCID,Shane Janelle C.⁴^ORCID,McKnight Douglas J.⁴^ORCID,Yoshizawa Susumu⁵^ORCID,Kato Hideaki E.⁶^ORCID,Ganguli Surya³,Deisseroth Karl¹²⁷⁸^ORCID

Affiliation:

1. CNC Department, Stanford University, Stanford, CA 94305, USA.

2. Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.

3. Department of Applied Physics, Stanford University, Stanford, CA 94305, USA.

4. Boulder Nonlinear Systems, Lafayette, CO 80026, USA.

5. Department of Natural Environmental Studies, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa 277-8564, Japan.

6. Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA.

7. Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.

8. Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.

Abstract

Brain circuit visualization and manipulation How are behaviorally relevant representations of the outside world initiated and manifested in the mammalian brain? Marshel et al. combined a channelrhodopsin with an improved holographic stimulation technique to examine activity in the mouse visual cortex, including its deep layers. Optogenetic stimulation of neurons previously activated by natural visual stimuli recreated the original activity and behavior. Neuronal population activity typically propagated from cortical layer 2/3 to layer 5 rather than in the reverse direction. Stimulation of a larger number of cells was required to initiate activity in layer 2/3 than in layer 5. This indicates differences in ensemble coding between the two layers. Science , this issue p. eaaw5202

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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