Random heteropolymers preserve protein function in foreign environments-Reference-Cited by-同舟云学术

Random heteropolymers preserve protein function in foreign environments

Published:2018-03-16 Issue:6381 Volume:359 Page:1239-1243
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Panganiban Brian¹^ORCID,Qiao Baofu²^ORCID,Jiang Tao¹^ORCID,DelRe Christopher¹^ORCID,Obadia Mona M.³^ORCID,Nguyen Trung Dac²^ORCID,Smith Anton A. A.¹^ORCID,Hall Aaron¹^ORCID,Sit Izaac¹^ORCID,Crosby Marquise G.⁴^ORCID,Dennis Patrick B.⁴^ORCID,Drockenmuller Eric³^ORCID,Olvera de la Cruz Monica²⁵,Xu Ting¹⁶⁷⁸^ORCID

Affiliation:

1. Department of Materials Science and Engineering, University of California, Berkeley, Berkeley, CA 94720, USA.

2. Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.

3. Université Lyon, Université Lyon 1, CNRS, Ingénierie des Matériaux Polymères, UMR 5223, F-69003 Lyon, France.

4. Air Force Research Laboratory, Wright-Patterson Air Force Base, OH 45433, USA.

5. Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.

6. Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.

7. Materials Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

8. Tsinghua-Berkeley Shenzhen Institute, University of California, Berkeley, Berkeley, CA 94720, USA.

Abstract

Mimicking the designs found in proteins Natural proteins combine a range of useful features, including chemical diversity, the ability to rapidly switch between preprogrammed shapes, and a hierarchy of structures. Panganiban et al. designed random copolymers with polar and nonpolar groups, using many of the features found in proteins (see the Perspective by Alexander-Katz and Van Lehn). Their structures could serve as “broad spectrum” surfactants, able to promote the solubilization of proteins in organic solvents and help preserve the functionality of proteins in aqueous environments. Science , this issue p. 1239 ; see also p. 1216

Funder

Sherman Fairchild Foundation

Department of Defense, Army Research Office

Department of Energy Basica Energy Science

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference51 articles.

1. Improving enzymes by using them in organic solvents

2. Amphipols: polymeric surfactants for membrane biology research

3. Controlled Radical Polymerization as an Enabling Approach for the Next Generation of Protein–Polymer Conjugates