The Landscape of C. elegans 3′UTRs-Reference-Cited by-同舟云学术

The Landscape of C. elegans 3′UTRs

Published:2010-07-23 Issue:5990 Volume:329 Page:432-435
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Mangone Marco¹,Manoharan Arun Prasad²,Thierry-Mieg Danielle³,Thierry-Mieg Jean³,Han Ting²,Mackowiak Sebastian D.⁴,Mis Emily¹,Zegar Charles¹,Gutwein Michelle R.¹,Khivansara Vishal²,Attie Oliver¹,Chen Kevin¹⁴,Salehi-Ashtiani Kourosh⁵⁶,Vidal Marc⁵⁶,Harkins Timothy T.⁷,Bouffard Pascal⁸,Suzuki Yutaka⁹,Sugano Sumio⁹,Kohara Yuji¹⁰,Rajewsky Nikolaus⁴,Piano Fabio¹¹¹,Gunsalus Kristin C.¹¹¹,Kim John K.²

Affiliation:

1. Center for Genomics and Systems Biology, Department of Biology, New York University, 1009 Silver Center, New York, NY 10003, USA.

2. Life Sciences Institute, Department of Human Genetics, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109–2216, USA.

3. National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.

4. Max Delbrück Centrum für Molekulare Medizin, Robe Rössle-Strasse 10, Berlin-Buch, 13092 Berlin, Germany.

5. Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute (DFCI), Boston, MA 02115, USA.

6. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

7. Roche Applied Science, Indianapolis, IN 46250, USA.

8. 454 Life Sciences, Roche Applied Science, Branford, CT 06405, USA.

9. Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, 4-6-1 Shirokanedai, Minatoku, Tokyo 108-8639, Japan.

10. Genome Biology Lab Center for Genetic Resource Information, National Institute of Genetics, Mishima 411-8540, Japan.

11. New York University, Abu Dhabi, United Arab Emirates.

Abstract

A New Look at Old Data Although the full genome of Caenorhabditis elegans has been available for over 10 years, only a portion of the full-length messenger RNAs (mRNAs) and their expression through development has been analyzed. By combining multiple methods, involving a careful reannotation of existing data sets, sequencing of poly-A captured RNAs from multiple developmental stages, as well as cloning and deep sequencing of a subset of genes, Mangone et al. (p. 432 , published online 3 June) defined ∼26,000 distinct mRNA three-prime untranslated regions (3′UTRs) for ∼85% of the protein-coding genes. Most C. elegans genes have more than one 3′UTR, arising through different mechanisms including trans-splicing–coupled cleavage and polyadenylation. The work highlights the importance of the 3'UTRs in the regulation of mRNA stability and translation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference23 articles.

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