Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis-Reference-Cited by-同舟云学术

Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis

Published:2019-03-08 Issue:6431 Volume:363 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ladinsky Mark S.¹^ORCID,Araujo Leandro P.²^ORCID,Zhang Xiao³^ORCID,Veltri John⁴,Galan-Diez Marta²^ORCID,Soualhi Salima²^ORCID,Lee Carolyn²,Irie Koichiro²⁵,Pinker Elisha Y.²^ORCID,Narushima Seiko⁶^ORCID,Bandyopadhyay Sheila³^ORCID,Nagayama Manabu⁶⁷^ORCID,Elhenawy Wael⁸,Coombes Brian K.⁸^ORCID,Ferraris Ronaldo P.⁴,Honda Kenya⁶⁹^ORCID,Iliev Iliyan D.¹⁰^ORCID,Gao Nan³,Bjorkman Pamela J.¹^ORCID,Ivanov Ivaylo I.²^ORCID

Affiliation:

1. Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

2. Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

3. Department of Biological Sciences, Rutgers University, Newark, NJ 07102, USA.

4. Department of Pharmacology, Physiology and Neurosciences, Rutgers University, Newark, NJ 07103, USA.

5. Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

6. RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan.

7. Department of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi 329-0498, Japan.

8. Department of Biochemistry & Biomedical Sciences, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.

9. Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo 160-8582, Japan.

10. Department of Microbiology and Immunology and The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York, NY 10065, USA.

Abstract

Hooking into antigen transfer Segmented filamentous bacteria (SFB) are anaerobic, spore-forming, clostridia-like organisms that are important immune modulators in the mammalian gut. For some reason, SFB do not provoke inflammatory responses. Ladinsky et al. probed the mechanistic basis of this soothing effect in mice. SFB attach tightly to intestinal epithelial cells via a hook-like structure. Bacterial material is extruded from the hook and enters the host cell by endocytosis. An extruded SFB protein called P3340 is shuttled by the host protein cell division control protein 42 homolog (CDC42) through the endosomelysosome vesicular pathway to the basolateral side of the intestinal epithelial cell. Here, it prompts an immunomodulatory SFB-specific CD4 T helper 17 cell response, possibly via intestinal macrophages. Science , this issue p. eaat4042

Funder

National Science Foundation

National Institutes of Health

American Cancer Society

Canadian Institutes of Health Research

Pew Charitable Trusts

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference40 articles.

1. Immune adaptations that maintain homeostasis with the intestinal microbiota