Construction of Synthetic Immunogen: Use of New T-Helper Epitope on Malaria Circumsporozoite Protein

Author:

Good Michael F.1,Maloy W. Lee2,Lunde Milford N.1,Margalit Hanah3,Cornette James L.3,Smith Geoffrey L.4,Moss Bernard4,Miller Louis H.1,Berzofsky Jay A.5

Affiliation:

1. Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of H Bethesda, MD 20892.

2. Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.

3. Laboratory of Mathematical Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

4. Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD 20892.

5. Metabolism Branch, National Institutes of Health, Bethesda, MD 20892.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference16 articles.

1. BERZOFSKY, J.A., T-B RECIPROCITY - AN IA-RESTRICTED EPITOPE-SPECIFIC CIRCUIT REGULATING T-CELL-B-CELL INTERACTION AND ANTIBODY SPECIFICITY, SURVEY OF IMMUNOLOGIC RESEARCH 2: 223 (1983).

2. CHEN, D.H., IMMUNITY TO SPOROZOITE-INDUCED MALARIA INFECTION IN MICE .1. EFFECT OF IMMUNIZATION OF T AND B CELL DEFICIENT MICE, JOURNAL OF IMMUNOLOGY 118: 1322 (1977).

3. CORRADIN, G, LYMPHOCYTE SPECIFICITY TO PROTEIN ANTIGENS .1. CHARACTERIZATION OF ANTIGEN-INDUCED INVITRO T-CELL-DEPENDENT PROLIFERATIVE RESPONSE WITH LYMPH-NODE CELLS FROM PRIMED MICE, JOURNAL OF IMMUNOLOGY 119: 1048 (1977).

4. Structure of the Gene Encoding the Immunodominant Surface Antigen on the Sporozoite of the Human Malaria Parasite Plasmodium falciparum

5. DELGIUDICE, G, THE ANTIBODY-RESPONSE IN MICE TO CARRIER-FREE SYNTHETIC-POLYMERS OF PLASMODIUM-FALCIPARUM CIRCUMSPOROZOITE REPETITIVE EPITOPE IS I-AB-RESTRICTED - POSSIBLE IMPLICATIONS FOR MALARIA VACCINES, JOURNAL OF IMMUNOLOGY 137: 2952 (1986).

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