The Cells and Circuitry for Itch Responses in Mice-Reference-Cited by-同舟云学术

The Cells and Circuitry for Itch Responses in Mice

Published:2013-05-24 Issue:6135 Volume:340 Page:968-971
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Mishra Santosh K.¹,Hoon Mark A.¹

Affiliation:

1. Molecular Genetics Unit, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research (NIDCR), NIH, Building 49, Room 1A16, 49 Convent Drive, Bethesda, MD 20892, USA.

Abstract

The Master Switch for Itch? Recently, gastrin-releasing peptide (GRP) has been implicated as the primary neurotransmitter between itch-sensitive nerve fibers and downstream neurons in the spinal cord. However, Mishra and Hoon (p. 968 ) challenge this view, provide evidence that natriuretic polypeptide b (Nppb) is the central itch neurotransmitter, and suggest that GRP is released by second-order neurons in the spinal dorsal horn that express the Nppb receptor and are excited by Nppb.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference25 articles.

1. TRPV1 Mediates Histamine-Induced Itching via the Activation of Phospholipase A2 and 12-Lipoxygenase

2. TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms

3. Phospholipase Cβ 3 Mediates the Scratching Response Activated by the Histamine H1 Receptor on C-Fiber Nociceptive Neurons

4. Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli

5. A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord

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