Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain-Reference-Cited by-同舟云学术

Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain

Published:2013-06-28 Issue:6140 Volume:340 Page:1567-1570
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Lapuente-Brun Esther¹²,Moreno-Loshuertos Raquel²,Acín-Pérez Rebeca¹,Latorre-Pellicer Ana¹,Colás Carmen¹,Balsa Eduardo¹³,Perales-Clemente Ester¹,Quirós Pedro M.⁴,Calvo Enrique²,Rodríguez-Hernández M. A.⁵,Navas Plácido⁵,Cruz Raquel⁶,Carracedo Ángel⁶,López-Otín Carlos⁴,Pérez-Martos Acisclo²,Fernández-Silva Patricio²,Fernández-Vizarra Erika⁷,Enríquez José Antonio¹²

Affiliation:

1. Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.

2. Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Zaragoza 50009, Spain.

3. Servicio de Inmunología, Hospital Universitario de La Princesa, Universidad Autónoma de Madrid, Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid 28006, Spain.

4. Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006-Oviedo, Spain.

5. Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide-CSIC and Centro de Investigación Biomédica en Red de Enfermedades Raras, ISCIII, Sevilla 41013 Spain.

6. Grupo de Medicina Xenómica, Facultad de Medicina, Centro de Investigación Biomédica en Red de Enfermedades Raras, Universidad de Santiago de Compostela 15782 Santiago de Compostela, A Coruña, Spain.

7. IIS Aragón, Unidad de Investigación Traslacional Instituto Aragones de Ciencias de la Salud, Hospital Universitario Miguel Servet, Zaragoza 50009, Spain.

Abstract

Respiration Refined Cells derive energy from redox reactions mediated by mitochondrial enzymes that form the electron transport chain. The enzymes can form large complexes, known as supercomplexes, whose function has been controversial. Lapuente-Brun et al. (p. 1567 ) discovered that a mouse protein, supercomplex assembly factor I (SCAFI), specifically modulates assembly of respiratory complexes into supercomplexes. Formation of the supercomplexes appears to cause electrons to be processed differently, depending on the substrate from which they are derived.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference27 articles.

1. The random collision model and a critical assessment of diffusion and collision in mitochondrial electron transport

2. Supercomplexes in the respiratory chains of yeast and mammalian mitochondria

3. Kinetics of integrated electron transfer in the mitochondrial respiratory chain: random collisions vs. solid state electron channeling

4. Respiratory Active Mitochondrial Supercomplexes

5. Respiratory Complex III Is Required to Maintain Complex I in Mammalian Mitochondria

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