Structures of PI4KIIIβ complexes show simultaneous recruitment of Rab11 and its effectors-Reference-Cited by-同舟云学术

Structures of PI4KIIIβ complexes show simultaneous recruitment of Rab11 and its effectors

Published:2014-05-30 Issue:6187 Volume:344 Page:1035-1038
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Burke John E.¹,Inglis Alison J.¹,Perisic Olga¹,Masson Glenn R.¹,McLaughlin Stephen H.¹,Rutaganira Florentine²,Shokat Kevan M.²,Williams Roger L.¹

Affiliation:

1. Medical Research Council (MRC) Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.

2. Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.

Abstract

How to recruit membrane trafficking machinery PI4KIIIβ is a lipid kinase that underlies Golgi function and is enlisted in biological responses that require rapid delivery of membrane vesicles, such as during the extensive membrane remodeling that occurs at the end of cell division. Burke et al. determined the structure of PI4KIIIβ in a complex with the membrane trafficking GTPase Rab11a. The way in which the proteins interact gives PI4KIIIβ the ability to simultaneously recruit Rab11a and its effectors on specific membranes. Science , this issue p. 1035

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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