Operational redundancy in axon guidance through the multifunctional receptor Robo3 and its ligand NELL2-Reference-Cited by-同舟云学术

Operational redundancy in axon guidance through the multifunctional receptor Robo3 and its ligand NELL2

Published:2015-11-20 Issue:6263 Volume:350 Page:961-965
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Jaworski Alexander¹²³,Tom Irene⁴,Tong Raymond K.⁴,Gildea Holly K.³,Koch Alexander W.⁴,Gonzalez Lino C.⁴,Tessier-Lavigne Marc¹²

Affiliation:

1. Division of Research, Genentech, South San Francisco, CA 94080, USA.

2. Laboratory of Brain Development and Repair, The Rockefeller University, New York, NY 10065, USA.

3. Department of Neuroscience, Brown University, Providence, RI 02912, USA.

4. Department of Protein Chemistry, Genentech, South San Francisco, CA 94080, USA.

Abstract

No going back The mammalian spinal cord coordinates neuronal systems across the body. Axons that cross the spinal cord midline during development first need permission to cross and then instruction not to keep crossing back and forth. Jaworski et al. studied the axonal guidance receptor ROBO3 and found a ligand NELL2 in mice that appears to help in this process. Science , this issue p. 961

Funder

Genentech

Brown University

The Rockefeller University

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference27 articles.

1. Mechanisms and Molecules of Neuronal Wiring: A Primer

2. Navigating Intermediate Targets: The Nervous System Midline

3. Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord