Binding of Neuroligins to PSD-95-Reference-Cited by-同舟云学术

Binding of Neuroligins to PSD-95

Published:1997-09-05 Issue:5331 Volume:277 Page:1511-1515
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Irie M.¹²³,Hata Y.¹²³,Takeuchi M.¹²³,Ichtchenko K.¹²³,Toyoda A.¹²³,Hirao K.¹²³,Takai Y.¹²³,Rosahl T. W.¹²³,Südhof T. C.¹²³

Affiliation:

1. M. Irie, M. Takeuchi, A. Toyoda, K. Hirao, Takai Biotimer Project, ERATO, Japan Science and Technology Corporation, 2-2-10, Murotani, Nishi-ku, Kobe, 651-22, Japan. Y. Hata, Howard Hughes Medical Institute and Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235–9050, USA, and Takai Biotimer Project, ERATO, Japan Science and Technology Corporation, 2-2-10, Murotani, Nishi-ku, Kobe 651-22, Japan.

2. K. Ichtchenko, T. W. Rosahl, T. C. Südhof, Howard Hughes Medical Institute and Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235–9050, USA.

3. Y. Takai, Takai Biotimer Project ERATO, Japan Science and Technology Corporation, 2-2-10, Murotani, Nishi-ku, Kobe 651-22, Japan, and Department of Molecular Biology and Biochemistry, Osaka University Medical School, Suita 565, Japan.

Abstract

PSD-95 is a component of postsynaptic densities in central synapses. It contains three PDZ domains that localize N -methyl- d -aspartate receptor subunit 2 (NMDA2 receptor) and K + channels to synapses. In mouse forebrain, PSD-95 bound to the cytoplasmic COOH-termini of neuroligins, which are neuronal cell adhesion molecules that interact with β-neurexins and form intercellular junctions. Neuroligins bind to the third PDZ domain of PSD-95, whereas NMDA2 receptors and K + channels interact with the first and second PDZ domains. Thus different PDZ domains of PSD-95 are specialized for distinct functions. PSD-95 may recruit ion channels and neurotransmitter receptors to intercellular junctions formed between neurons by neuroligins and β-neurexins.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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