The Minor Histocompatibility Antigen HA-1: A Diallelic Gene with a Single Amino Acid Polymorphism-Reference-Cited by-同舟云学术

The Minor Histocompatibility Antigen HA-1: A Diallelic Gene with a Single Amino Acid Polymorphism

Published:1998-02-13 Issue:5353 Volume:279 Page:1054-1057
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

den Haan Joke M. M.¹²³⁴,Meadows Leslie M.¹²³⁴,Wang Wei¹²³⁴,Pool Jos¹²³⁴,Blokland Els¹²³⁴,Bishop Tracie L.¹²³⁴,Reinhardus Carla¹²³⁴,Shabanowitz Jeffrey¹²³⁴,Offringa Rienk¹²³⁴,Hunt Donald F.¹²³⁴,Engelhard Victor H.¹²³⁴,Goulmy Els¹²³⁴

Affiliation:

1. J. M. M. den Haan, J. Pool, E. Blokland, C. Reinhardus, R. Offringa, E. Goulmy, Department of Immunohematology and Bloodbank, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.

2. L. M. Meadows, T. L. Bishop, J. Shabanowitz, Department of Chemistry, University of Virginia, Charlottesville, VA 22901, USA.

3. W. Wang and V. H. Engelhard, Department of Microbiology and the Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA.

4. D. F. Hunt, Departments of Chemistry and Pathology, University of Virginia, Charlottesville, VA 22901, USA.

Abstract

The minor histocompatibility antigen (mHag) HA-1 is the only known mHag for which mismatching is correlated with the development of severe graft versus host disease (GvHD) after human leukocyte antigen–identical bone marrow transplantation. HA-1 was found to be a nonapeptide derived from an allele of the KIAA0223 gene. The HA-1–negative allelic counterpart encoded by KIAA0223 had one amino acid difference from HA-1. Family analysis with HA-1 allele-specific polymerase chain reaction showed an exact correlation between this allelic polymorphism and the HA-1 phenotype. HA-1 allele typing of donor and recipient should improve donor selection and allow the determination of bone marrow transplantation recipients with high risk for HA-1–induced GvHD development.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference44 articles.

1. Beatty P. G., et al., Transplantation 51, 443 (1991);

2. Marks D. I., et al., Ann. Intern. Med. 119, 207 (1993).

3. Identification of a Graft Versus Host Disease-Associated Human Minor Histocompatibility Antigen

4. Wang W., et al., ibid. 269, 1588 (1995).

5. Meadows L., et al., Immunity 6, 273 (1997).

Cited by 373 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. HA-1–targeted T-cell receptor T-cell therapy for recurrent leukemia after hematopoietic stem cell transplantation;Blood;2024-09-05

2. Innovations Toward Immunopeptidomics;Molecular & Cellular Proteomics;2024-09

3. Minor histocompatibility antigens to predict, monitor or manipulate GvL and GvHD after allogeneic hematopoietic cell transplantation;Best Practice & Research Clinical Haematology;2024-06

4. Hidden treasures of histocompatibility;Blood;2024-05-02

5. Experimental Data on PIRCHE and T-Cell Reactivity: HLA-DPB1-Derived Peptides Identified by PIRCHE-I Show Binding to HLA-A*02:01 in vitro and T-Cell Activation in vivo;Transfusion Medicine and Hemotherapy;2024