Inhibition of Phosphatases and Increased Ca 2+ Channel Activity by Inositol Hexakisphosphate-Reference-Cited by-同舟云学术

Inhibition of Phosphatases and Increased Ca 2+ Channel Activity by Inositol Hexakisphosphate

Published:1997-10-17 Issue:5337 Volume:278 Page:471-474
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Larsson Olof¹²³⁴⁵,Barker Christopher J.¹²³⁴⁵,Sjöholm Åke¹²³⁴⁵,Carlqvist Håkan¹²³⁴⁵,Michell Robert H.¹²³⁴⁵,Bertorello Alejandro¹²³⁴⁵,Nilsson Thomas¹²³⁴⁵,Honkanen Richard E.¹²³⁴⁵,Mayr Georg W.¹²³⁴⁵,Zwiller Jean¹²³⁴⁵,Berggren Per-Olof¹²³⁴⁵

Affiliation:

1. O. Larsson, C. J. Barker, Å. Sjöholm, A. Bertorello, T. Nilsson, P.-O. Berggren, Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Institute, S-171 76 Stockholm, Sweden.

2. H. Carlqvist, Astra Pain Control AB, Cellular and Molecular Pharmacology, Novum Unit, S-141 57 Huddinge, Sweden.

3. R. H. Michell, School of Biochemistry, University of Birmingham, Post Office Box 363, Birmingham B15 2TT, UK.

4. R. E. Honkanen, Department of Biochemistry, MSB 2198, College of Medicine, University of South Alabama, Mobile, AL 36688, USA.

5. G. W. Mayr, Institut für Physiologische Chemie, Universitäts-Krankenhaus Eppendorf, 20246 Hamburg, Germany.

Abstract

Inositol hexakisphosphate (InsP 6 ), the dominant inositol phosphate in insulin-secreting pancreatic β cells, inhibited the serine-threonine protein phosphatases type 1, type 2A, and type 3 in a concentration-dependent manner. The activity of voltage-gated L-type calcium channels is increased in cells treated with inhibitors of serine-threonine protein phosphatases. Thus, the increased calcium channel activity obtained in the presence of InsP 6 might result from the inhibition of phosphatase activity. Glucose elicited a transient increase in InsP 6 concentration, which indicates that this inositol polyphosphate may modulate calcium influx over the plasma membrane and serve as a signal in the pancreatic β cell stimulus-secretion coupling.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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