PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D-Reference-Cited by-同舟云学术

PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D

Published:2017-03-24 Issue:6331 Volume:355 Page:1324-1330
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Toska Eneda¹^ORCID,Osmanbeyoglu Hatice U.²,Castel Pau¹³^ORCID,Chan Carmen¹^ORCID,Hendrickson Ronald C.⁴^ORCID,Elkabets Moshe¹⁵^ORCID,Dickler Maura N.⁶,Scaltriti Maurizio¹⁷^ORCID,Leslie Christina S.²^ORCID,Armstrong Scott A.⁸⁹^ORCID,Baselga José¹⁶^ORCID

Affiliation:

1. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA.

2. Computational Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 460, New York, NY 10065, USA.

3. Helen Diller Family Comprehensive Cancer Center, University of California–San Francisco, 1450 3rd Street, San Francisco, CA 94158, USA.

4. Microchemistry and Proteomics Core Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

5. The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.

6. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

7. Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

8. Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

9. Department of Pediatric Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.

Abstract

Tumor cells develop resistance to a drug used to treat breast cancer through a chromatin remodeling mechanism.

Funder

Breast Cancer Research Foundation

Geoffrey Beene Cancer Research Center

NIH

NCI

Terri Brodeur Breast Cancer Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference44 articles.

1. Comprehensive molecular portraits of human breast tumours

2. Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

3. Abstract LB-64: GDC-0032, a beta isoform-sparing PI3K inhibitor: Results of a first-in-human phase Ia dose escalation study.

4. Abstract CT330: Phase I study of PI3Kα inhibitor BYL719 + aromatase inhibitor (AI) in patients (pts) with hormone receptor-positive (HR+) metastatic breast cancer (MBC)

5. Measurement of PIP3 Levels Reveals an Unexpected Role for p110β in Early Adaptive Responses to p110α-Specific Inhibitors in Luminal Breast Cancer

Cited by 218 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Histone-methyltransferase KMT2D deficiency impairs the Fanconi anemia/BRCA pathway upon glycolytic inhibition in squamous cell carcinoma;Nature Communications;2024-08-08

2. Essential gene screening identifies the bromodomain-containing protein BRPF1 as a new actionable target for endocrine therapy-resistant breast cancers;Molecular Cancer;2024-08-07

3. The histone methyltransferase KMT2D maintains cellular glucocorticoid responsiveness by shielding the glucocorticoid receptor from degradation;Journal of Biological Chemistry;2024-08

4. KMT2D‐mediated H3K4me1 recruits YBX1 to facilitate triple‐negative breast cancer progression through epigenetic activation of c‐Myc;Clinical and Translational Medicine;2024-07

5. KMT2C and KMT2D aberrations in breast cancer;Trends in Cancer;2024-06