Affiliation:
1. Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.
Abstract
Visualizing Xist RNA dynamics
The noncoding RNA Xist, which controls the process of X chromosome inactivation in mammals, accumulates and spreads over the chromosome from which it is transcribed. The underlying basis for this unusual behavior is poorly understood. Using a new imaging approach called RNA-SPLIT for time-resolved analysis of Xist RNA molecules at super-resolution, Rodermund
et al.
analyzed fundamental parameters of Xist RNA behavior in normal cells and after the perturbation of factors implicated in Xist RNA function. The authors provide new insights into the basis of Xist RNA localization and confinement within the territory of a single X chromosome.
Science
, abe7500, this issue p.
eabe7500
Funder
Wellcome
Medical Research Council UK
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
44 articles.
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