Functional CpG Methylation System in a Social Insect-Reference-Cited by-同舟云学术

Functional CpG Methylation System in a Social Insect

Published:2006-10-27 Issue:5799 Volume:314 Page:645-647
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Wang Ying¹²³⁴⁵,Jorda Mireia¹²³⁴⁵,Jones Peter L.¹²³⁴⁵,Maleszka Ryszard¹²³⁴⁵,Ling Xu¹²³⁴⁵,Robertson Hugh M.¹²³⁴⁵,Mizzen Craig A.¹²³⁴⁵,Peinado Miguel A.¹²³⁴⁵,Robinson Gene E.¹²³⁴⁵

Affiliation:

1. Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

2. IDIBELL–Cancer Research Institute, L'Hospitalet 08907, Catalonia, Spain.

3. Visual Sciences and Australian Research Council Centre for Molecular Genetics of Development, Research School of Biological Sciences, The Australian National University, Canberra, Australia.

4. Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

5. Department of Entomology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

Abstract

DNA methylation systems are well characterized in vertebrates, but methylation in Drosophila melanogaster and other invertebrates remains controversial. Using the recently sequenced honey bee genome, we present a bioinformatic, molecular, and biochemical characterization of a functional DNA methylation system in an insect. We report on catalytically active orthologs of the vertebrate DNA methyltransferases Dnmt1 and Dnmt3a and b, two isoforms that contain a methyl-DNA binding domain, genomic 5-methyl-deoxycytosine, and CpG-methylated genes. The honey bee provides an opportunity to study the roles of methylation in social contexts.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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