Replication timing maintains the global epigenetic state in human cells-Reference-Cited by-同舟云学术

Replication timing maintains the global epigenetic state in human cells

Published:2021-04-23 Issue:6540 Volume:372 Page:371-378
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Klein Kyle N.¹^ORCID,Zhao Peiyao A.¹^ORCID,Lyu Xiaowen²³^ORCID,Sasaki Takayo¹⁴,Bartlett Daniel A.¹^ORCID,Singh Amar M.⁵,Tasan Ipek⁶^ORCID,Zhang Meng⁶^ORCID,Watts Lotte P.⁷^ORCID,Hiraga Shin-ichiro⁷^ORCID,Natsume Toyoaki⁸⁹^ORCID,Zhou Xuemeng¹⁰^ORCID,Baslan Timour¹¹,Leung Danny¹⁰^ORCID,Kanemaki Masato T.⁸⁹^ORCID,Donaldson Anne D.⁷^ORCID,Zhao Huimin⁶^ORCID,Dalton Stephen⁵^ORCID,Corces Victor G.²^ORCID,Gilbert David M.¹⁴^ORCID

Affiliation:

1. Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.

2. Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.

3. State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, China.

4. San Diego Biomedical Research Institute, La Jolla, CA 92121, USA.

5. Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.

6. Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

7. Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK.

8. Department of Chromosome Science, National Institute of Genetics, Research Organization of Information and Systems (ROIS), Yata 1111, Mishima, Shizuoka 411-8540, Japan.

9. Department of Genetics, The Graduate University for Advanced Studies (SOKENDAI), Yata 1111, Mishima, Shizuoka 411-8540, Japan.

10. Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.

11. Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Abstract

Replication timing organizes epigenome The temporal order of DNA replication is conserved from yeast to humans, but its biological significance remains unclear. Klein et al. eliminated the protein RIF1, a master regulator of replication timing, in several human cell lines. RIF1 loss during the G1 phase of the cell cycle resulted in a heterogeneous, nearly random replication timing program from the first S phase that persisted even in stable RIF1-null clones. Altered replication timing was followed by replication-dependent redistribution of active and repressive histone modifications and alterations in genome architecture. These results support a model in which replication timing orchestrates the epigenetic state of newly replicated chromatin. Science , this issue p. 371

Funder

National Institutes of Health

Research Grants Council, University Grants Committee, Hong Kong

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference35 articles.

1. DNA Replication Timing

2. Accurate Recycling of Parental Histones Reproduces the Histone Modification Landscape during DNA Replication

3. Active and Repressed Chromatin Domains Exhibit Distinct Nucleosome Segregation during DNA Replication

4. Establishment of transcriptional competence in early and late S phase

5. Shifts in Replication Timing Actively Affect Histone Acetylation during Nucleosome Reassembly

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