Identification and Rescue of α-Synuclein Toxicity in Parkinson Patient–Derived Neurons-Reference-Cited by-同舟云学术

Identification and Rescue of α-Synuclein Toxicity in Parkinson Patient–Derived Neurons

Published:2013-11-22 Issue:6161 Volume:342 Page:983-987
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Chung Chee Yeun¹,Khurana Vikram¹²,Auluck Pavan K.¹³,Tardiff Daniel F.¹,Mazzulli Joseph R.²,Soldner Frank¹,Baru Valeriya¹⁴,Lou Yali¹⁴,Freyzon Yelena¹,Cho Sukhee⁵,Mungenast Alison E.⁵,Muffat Julien¹,Mitalipova Maisam¹,Pluth Michael D.⁶,Jui Nathan T.⁶,Schüle Birgitt⁷,Lippard Stephen J.⁶,Tsai Li-Huei⁴⁵,Krainc Dimitri²,Buchwald Stephen L.⁶,Jaenisch Rudolf¹⁸,Lindquist Susan¹⁴⁸

Affiliation:

1. Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

2. Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

3. Department of Pathology (Neuropathology), Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

4. Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.

5. The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

6. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

7. The Parkinson’s Institute, Sunnyvale, CA 94085,USA.

8. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.

Abstract

From Yeast to Therapeutic? Yeast has shown some promise as a model system to generate lead compounds that could have therapeutic potential for the cellular problems associated with neurodegenerative diseases. Along these lines, Tardiff et al. (p. 979 , published online 24 October) and Chung et al. (p. 983 , published online 24 October) describe the results of multiple screens in yeast that lead to the identification of a potential therapeutic compound to combat the cytotoxic affect of α-synuclein accumulation. The compound was able to reverse the pathological hallmarks of Parkinson's disease in cultured neurons derived from patients with α-synuclein–induced Parkinson's disease dementia.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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