Innate Lymphoid Cells Promote Anatomical Containment of Lymphoid-Resident Commensal Bacteria-Reference-Cited by-同舟云学术

Innate Lymphoid Cells Promote Anatomical Containment of Lymphoid-Resident Commensal Bacteria

Published:2012-06-08 Issue:6086 Volume:336 Page:1321-1325
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Sonnenberg Gregory F.¹,Monticelli Laurel A.¹,Alenghat Theresa¹,Fung Thomas C.¹,Hutnick Natalie A.²,Kunisawa Jun³⁴,Shibata Naoko³⁴,Grunberg Stephanie¹,Sinha Rohini¹,Zahm Adam M.⁵,Tardif Mélanie R.⁶,Sathaliyawala Taheri⁷,Kubota Masaru⁷,Farber Donna L.⁷,Collman Ronald G.⁸,Shaked Abraham⁹,Fouser Lynette A.¹⁰,Weiner David B.²,Tessier Philippe A.⁶,Friedman Joshua R.⁵,Kiyono Hiroshi³⁴¹¹,Bushman Frederic D.¹,Chang Kyong-Mi⁸¹²,Artis David¹¹³

Affiliation:

1. Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2. Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

3. Division of Mucosal Immunology, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.

4. Department of Medical Genome Science, Graduate School of Frontier Science, The University of Tokyo, Chiba 277-8562, Japan.

5. Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Perelman School of Medicine, University of Pennsylvania, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

6. Centre de Recherche en Infectiologie, Centre Hospitalier de l’Université Laval, Faculty of Medicine, Laval University, Quebec, Canada.

7. Department of Surgery and the Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA.

8. Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

9. Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA.

10. Inflammation and Immunology Research Unit, Biotherapeutics Research and Development, Pfizer Worldwide R&D, Cambridge, MA 02140, USA.

11. Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo 102-0075, Japan.

12. Philadelphia VA Medical Center, Philadelphia, PA 19104, USA.

13. Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

Protecting Against a Barrier Breach In order to coexist peacefully, a “firewall” exists that keeps the commensal bacteria that reside in our intestines and associated lymphoid tissue contained. Several diseases and infections, however, lead to a breach in this barrier, which leads to chronic inflammation and pathology. Sonnenberg et al. (p. 1321 ) found that in mice, innate lymphoid cells (ILCs) are critically important for the anatomical containment of commensal bacteria in an interleukin-22 (IL-22)–dependent manner. ILC depletion or blockade of IL-22 led to loss of bacterial containment and systemic inflammation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference30 articles.

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