Human DNA Repair Genes-Reference-Cited by-同舟云学术

Human DNA Repair Genes

Published:2001-02-16 Issue:5507 Volume:291 Page:1284-1289
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Wood Richard D.¹,Mitchell Michael²,Sgouros John²,Lindahl Tomas¹

Affiliation:

1. Imperial Cancer Research Fund, Clare Hall Laboratories, Blanche Lane, South Mimms, Herts EN6 3LD, UK.

2. Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

Abstract

Cellular DNA is subjected to continual attack, both by reactive species inside cells and by environmental agents. Toxic and mutagenic consequences are minimized by distinct pathways of repair, and 130 known human DNA repair genes are described here. Notable features presently include four enzymes that can remove uracil from DNA, seven recombination genes related to RAD51, and many recently discovered DNA polymerases that bypass damage, but only one system to remove the main DNA lesions induced by ultraviolet light. More human DNA repair genes will be found by comparison with model organisms and as common folds in three-dimensional protein structures are determined. Modulation of DNA repair should lead to clinical applications including improvement of radiotherapy and treatment with anticancer drugs and an advanced understanding of the cellular aging process.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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