Mutation of BCL-6 Gene in Normal B Cells by the Process of Somatic Hypermutation of Ig Genes-Reference-Cited by-同舟云学术

Mutation of BCL-6 Gene in Normal B Cells by the Process of Somatic Hypermutation of Ig Genes

Published:1998-06-12 Issue:5370 Volume:280 Page:1750-1752
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Shen Hong Ming¹²³⁴,Peters Andrew¹²³⁴,Baron Beverly¹²³⁴,Zhu Xiangdong¹²³⁴,Storb Ursula¹²³⁴

Affiliation:

1. H. M. Shen and U. Storb, Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60617, USA.

2. A. Peters, Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60617, USA.

3. B. Baron, Department of Pathology, University of Chicago, Chicago, IL 60617, USA.

4. X. Zhu, Department of Medicine, University of Chicago, Chicago, IL 60617, USA.

Abstract

Immunoglobulin (Ig) genes are hypermutated in B lymphocytes that are the precursors to memory B cells. The mutations are linked to transcription initiation, but non-Ig promoters are permissible for the mutation process; thus, other genes expressed in mutating B cells may also be subject to somatic hypermutation. Significant mutations were not observed in c- MYC , S14 , or α-fetoprotein ( AFP ) genes, but BCL-6 was highly mutated in a large proportion of memory B cells of normal individuals. The mutation pattern was similar to that of Ig genes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference30 articles.

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