Close Contacts with the Endoplasmic Reticulum as Determinants of Mitochondrial Ca 2+ Responses-Reference-Cited by-同舟云学术

Close Contacts with the Endoplasmic Reticulum as Determinants of Mitochondrial Ca 2+ Responses

Published:1998-06-12 Issue:5370 Volume:280 Page:1763-1766
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Rizzuto Rosario¹²,Pinton Paolo¹²,Carrington Walter¹²,Fay Frederic S.¹²,Fogarty Kevin E.¹²,Lifshitz Lawrence M.¹²,Tuft Richard A.¹²,Pozzan Tullio¹²

Affiliation:

1. R. Rizzuto, P. Pinton, T. Pozzan, Department of Biomedical Sciences and the National Research Council Center for the Study of Biomembranes, University of Padova, Via Colombo 3, 35121 Padova, Italy.

2. W. Carrington, F. S. Fay, K. E. Fogarty, L. M. Lifshitz, R. A. Tuft, Biomedical Imaging Group, University of Massachusetts Medical Center, Worcester, MA 01605, USA.

Abstract

The spatial relation between mitochondria and endoplasmic reticulum (ER) in living HeLa cells was analyzed at high resolution in three dimensions with two differently colored, specifically targeted green fluorescent proteins. Numerous close contacts were observed between these organelles, and mitochondria in situ formed a largely interconnected, dynamic network. A Ca 2+ -sensitive photoprotein targeted to the outer face of the inner mitochondrial membrane showed that, upon opening of the inositol 1,4,5-triphosphate (IP 3 )–gated channels of the ER, the mitochondrial surface was exposed to a higher concentration of Ca 2+ than was the bulk cytosol. These results emphasize the importance of cell architecture and the distribution of organelles in regulation of Ca 2+ signaling.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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