ARGONAUTE4 Control of Locus-Specific siRNA Accumulation and DNA and Histone Methylation-Reference-Cited by-同舟云学术

ARGONAUTE4 Control of Locus-Specific siRNA Accumulation and DNA and Histone Methylation

Published:2003-01-31 Issue:5607 Volume:299 Page:716-719
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Zilberman Daniel¹,Cao Xiaofeng¹,Jacobsen Steven E.¹²

Affiliation:

1. Department of Molecular, Cell, and Developmental Biology,

2. Molecular Biology Institute, University of California, Los Angeles, CA 90095–1606.

Abstract

Proteins of the ARGONAUTE family are important in diverse posttranscriptional RNA-mediated gene-silencing systems as well as in transcriptional gene silencing in Drosophila and fission yeast and in programmed DNA elimination in Tetrahymena . We cloned ARGONAUTE4 ( AGO4 ) from a screen for mutants that suppress silencing of the Arabidopsis SUPERMAN ( SUP ) gene. The ago4-1 mutant reactivated silent SUP alleles and decreased CpNpG and asymmetric DNA methylation as well as histone H3 lysine-9 methylation. In addition, ago4-1 blocked histone and DNA methylation and the accumulation of 25-nucleotide small interfering RNAs (siRNAs) that correspond to the retroelement AtSN1 . These results suggest that AGO4 and long siRNAs direct chromatin modifications, including histone methylation and non-CpG DNA methylation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference23 articles.

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5. Establishment and Maintenance of a Heterochromatin Domain

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