Affiliation:
1. Department of Molecular and Cellular Biology, Division of Genetics, 401 Barker Hall, University of California, Berkeley, CA 94720, USA.
Abstract
Human CtBP attenuates transcriptional activation and tumorigenesis mediated by the adenovirus E1A protein. The E1A sequence motif that interacts with CtBP, Pro-X-Asp-Leu-Ser-X-Lys (P-DLS-K), is present in the repression domains of two unrelated short-range repressors in
Drosophila
, Knirps and Snail, and is essential for the interaction of these proteins with
Drosophila
CtBP (dCtBP). A P-element–induced mutation in dCtBP exhibits gene-dosage interactions with a null mutation in
knirps
, which is consistent with the occurrence of Knirps-dCtBP interactions in vivo. These observations suggest that CtBP and dCtBP are engaged in an evolutionarily conserved mechanism of transcriptional repression, which is used in both
Drosophila
and mammals.
Publisher
American Association for the Advancement of Science (AAAS)
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