Mechanism of Actin-Based Motility-Reference-Cited by-同舟云学术

Mechanism of Actin-Based Motility

Published:2001-05-25 Issue:5521 Volume:292 Page:1502-1506
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Pantaloni Dominique¹,Clainche Christophe Le¹,Carlier Marie-France¹

Affiliation:

1. Dynamique du Cytosquelette, Laboratoire d'Enzymologie et Biochimie Structurales, CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France.

Abstract

Spatially controlled polymerization of actin is at the origin of cell motility and is responsible for the formation of cellular protrusions like lamellipodia. The pathogens Listeria monocytogenes and Shigella flexneri , which undergo actin-based propulsion, are acknowledged models of the leading edge of lamellipodia. Actin-based motility of the bacteria or of functionalized microspheres can be reconstituted in vitro from only five pure proteins. Movement results from the regulated site-directed treadmilling of actin filaments, consistent with observations of actin dynamics in living motile cells and with the biochemical properties of the components of the synthetic motility medium.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference73 articles.

1. D. Bray Cell Movements: From Molecules to Motility (Garland New York ed. 2 2000).

2. Actin-Based Cell Motility and Cell Locomotion

3. Supplementary material is available as a Microsoft PowerPoint presentation on Science Online at www.sciencemag.org/cgi/content/full/292/5521/1502/DC1. The compressed files are 30 Mb (∼60 Mb uncompressed) and must be downloaded. When viewed as a slide show (full screen) the presentation shows cell movements animated chemical reaction diagrams and animated graphs. The viewer will need to push the down arrow on the keyboard at least once per slide (and sometimes up to four times) to view all of the frames and to move to the next slide. When a slide comes into view please wait a few seconds; sometimes the animation begins automatically other times the viewer must press the down arrow.

4. Spatial Control of Actin Filament Assembly

5. Secrets of actin-based motility revealed by a bacterial pathogen

Cited by 599 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Targeting Fascin1 maintains chondrocytes phenotype and attenuates osteoarthritis development;Bone Research;2024-09-04

2. On the generation of force required for actin-based motility;Scientific Reports;2024-08-08

3. Beam theory of cellular microfilaments based on coarse-grained molecular force field;Results in Physics;2024-03

4. Biophysical Modeling of Actin-Mediated Structural Plasticity Reveals Mechanical Adaptation in Dendritic Spines;eneuro;2024-02-21

5. Bsp1, a fungal CPI motif protein, regulates actin filament capping in endocytosis and cytokinesis;Molecular Biology of the Cell;2024-02-01