Gut microbiome heritability is nearly universal but environmentally contingent-Reference-Cited by-同舟云学术

Gut microbiome heritability is nearly universal but environmentally contingent

Published:2021-07-09 Issue:6551 Volume:373 Page:181-186
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Grieneisen Laura¹^ORCID,Dasari Mauna²^ORCID,Gould Trevor J.¹,Björk Johannes R.²^ORCID,Grenier Jean-Christophe³⁴^ORCID,Yotova Vania³^ORCID,Jansen David²^ORCID,Gottel Neil⁵^ORCID,Gordon Jacob B.⁶^ORCID,Learn Niki H.⁷,Gesquiere Laurence R.⁶^ORCID,Wango Tim L.⁸⁹,Mututua Raphael S.⁸,Warutere J. Kinyua⁸,Siodi Long’ida⁸,Gilbert Jack A.⁵^ORCID,Barreiro Luis B.³¹⁰,Alberts Susan C.⁶¹¹¹²^ORCID,Tung Jenny⁶¹¹¹²¹³^ORCID,Archie Elizabeth A.²^ORCID,Blekhman Ran¹¹⁴^ORCID

Affiliation:

1. Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA.

2. Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.

3. Department of Genetics, CHU Sainte Justine Research Center, Montréal, Quebec H3T 1C5, Canada.

4. Research Center, Montreal Heart Institute, Montréal, Quebec H1T 1C8, Canada.

5. Marine Biology Research Division, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093.

6. Department of Biology, Duke University, Durham, NC 27708, USA.

7. Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA.

8. Amboseli Baboon Research Project, Amboseli National Park, Kenya.

9. The Department of Veterinary Anatomy and Animal Physiology, University of Nairobi, Kenya.

10. Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.

11. Department of Evolutionary Anthropology, Duke University, Durham, NC 27708, USA.

12. Duke Population Research Institute, Duke University, Durham, NC 27708, USA.

13. Canadian Institute for Advanced Research, Toronto, Ontario M5G 1M1, Canada.

14. Department of Ecology, Evolution, and Behavior, University of Minnesota, Minneapolis, MN 55455, USA.

Abstract

Baboons inform on human gut microbiota Commensal bacteria are found throughout an organism, but it is not known whether associations between gut bacteria and their host are heritable. Grieneisen et al. examined changes in the microbiomes of 585 wild baboons from fecal samples collected over 14 years (see the Perspective by Cortes-Ortiz and Amato). Almost all microbiome traits tested demonstrated some level of statistically significant heritability. Most heritability values were low but varied over time correlating with the age of the host. Baboons live in an environment similar to that postulated for early humans and have a microbiome similar to that of humans. Thus, this heritability of the microbiome may reflect similar genetic determinants in humans, for which similar datasets are not available. Science , aba5483, this issue p. 181 ; see also abj5287, p. 159

Funder

National Science Foundation

National Institutes of Health

University of Minnesota Grand Challenges in Biology Postdoctoral Fellowship

National Institute on Aging

National Institute of Child Health and Human Development

Duke University

Duke University Population Research Institute

National Institute of General Medical Sciences

Princeton Center for the Demography of Aging

Princeton University

Publisher