Self-organization of parS centromeres by the ParB CTP hydrolase-Reference-Cited by-同舟云学术

Self-organization of parS centromeres by the ParB CTP hydrolase

Published:2019-11-29 Issue:6469 Volume:366 Page:1129-1133
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Soh Young-Min¹^ORCID,Davidson Iain Finley²^ORCID,Zamuner Stefano³,Basquin Jérôme⁴,Bock Florian Patrick¹^ORCID,Taschner Michael¹^ORCID,Veening Jan-Willem¹^ORCID,De Los Rios Paolo³,Peters Jan-Michael²^ORCID,Gruber Stephan¹^ORCID

Affiliation:

1. Department of Fundamental Microbiology (DMF), Faculty of Biology and Medicine (FBM), University of Lausanne (UNIL), Lausanne, Switzerland.

2. Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC) and Medical University of Vienna, Vienna, Austria.

3. Laboratory of Statistical Biophysics, Institute of Physics, School of Basic Sciences and Institute of Bioengineering, School of Life Sciences, École Polytechnique Féderale de Lausanne (EPFL), Lausanne, Switzerland.

4. Structural Cell Biology, Max Planck Institute of Biochemistry, Martinsried, Germany.

Abstract

CTP hydrolysis organizes chromosomes The bacterial DNA parS centromere recruits the ParB protein to the bacterial chromosome. Soh et al. found that the widespread family of ParB proteins not only bind DNA but also bind and hydrolyze cytidine triphosphate (CTP) (see the Perspective by Funnell). ParB CTP hydrolysis is stimulated by parS and regulates the spreading of ParB protein to the parS flanking regions, which is crucial for organizing the bacterial chromosome. The cytidine triphosphatase domain is conserved in a large variety of protein sequences, suggesting its potential roles in other cellular processes. Science , this issue p. 1129 ; see also p. 1072

Funder

H2020 European Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference30 articles.

1. Subcellular Organization: A Critical Feature of Bacterial Cell Replication

2. Identification and Characterization of a Bacterial Chromosome Partitioning Site

3. Cell-free study of F plasmid partition provides evidence for cargo transport by a diffusion-ratchet mechanism

4. Evidence for a DNA-relay mechanism in ParABS-mediated chromosome segregation

5. SMC condensin entraps chromosomal DNA by an ATP hydrolysis dependent loading mechanism in Bacillus subtilis

Cited by 125 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Genomic analysis of the degradation gene clusters and the parABS system in Afipia sp. strain DD3 capable of utilizing 2,4-dichlorophenoxyacetic acid;The Microbe;2024-09

2. In vivo assembly of bacterial partition condensates on circular supercoiled and linear DNA;Molecular Microbiology;2024-08-07

3. Unraveling the structure and function of a novel SegC protein interacting with the SegAB chromosome segregation complex in Archaea;Nucleic Acids Research;2024-07-30

4. Evolutionarily divergentMycobacterium tuberculosisCTP synthase filaments are under selective pressure;2024-07-25

5. DNA supercoiling enhances DNA condensation by ParB proteins;2024-07-13