Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope-Reference-Cited by-同舟云学术

Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope

Published:2018-06-22 Issue:6395 Volume:360 Page:1358-1362
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Imkeller Katharina¹²^ORCID,Scally Stephen W.³^ORCID,Bosch Alexandre³^ORCID,Martí Gemma Pidelaserra¹²^ORCID,Costa Giulia⁴^ORCID,Triller Gianna¹,Murugan Rajagopal¹^ORCID,Renna Valerio⁵^ORCID,Jumaa Hassan⁵^ORCID,Kremsner Peter G.⁶,Sim B. Kim Lee⁷^ORCID,Hoffman Stephen L.⁷^ORCID,Mordmüller Benjamin⁶^ORCID,Levashina Elena A.⁴^ORCID,Julien Jean-Philippe³⁸^ORCID,Wardemann Hedda¹^ORCID

Affiliation:

1. B Cell Immunology, German Cancer Research Institute, Heidelberg, Germany.

2. Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.

3. Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.

4. Vector Biology Unit, Max Planck Institute for Infection Biology, Berlin, Germany.

5. Institute of Immunology, University Medical Center Ulm, Ulm, Germany.

6. Institute of Tropical Medicine and German Center for Infection Research, Partner Site Tübingen, University of Tübingen, Tübingen, Germany.

7. Sanaria, Rockville, MD, USA.

8. Departments of Biochemistry and Immunology, University of Toronto, Toronto, ON, Canada.

Abstract

Surface antibody maturation Affinity maturation in B cells generates antibodies with increasingly enhanced antigen-binding properties. Imkeller et al. investigated the maturation of human B cells that express protective antibodies against the circumsporozoite protein of the malaria-causing parasite Plasmodium falciparum (PfCSP). The repetitive structure of PfCSP induces mutations in B cells, facilitating direct interactions between two repeat-bound antibodies against PfCSP, which enhance antigen affinity and B cell activation. Such interactions may optimize binding and promote clustering of surface antibodies in general. Science , this issue p. 1358

Funder

National Institutes of Health

Bill and Melinda Gates Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference33 articles.

1. Circumsporozoite proteins of malaria parasites contain a single immunodominant region with two or more identical epitopes.

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3. DNA Cloning of Plasmodium falciparum Circumsporozoite Gene: Amino Acid Sequence of Repetitive Epitope

4. Monovalent fragments (Fab) of monoclonal antibodies to a sporozoite surface antigen (Pb44) protect mice against malarial infection.

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