Affiliation:
1. Division of Biology, 156-29, California Institute of Technology, Pasadena, CA 91125, USA.
Abstract
Early specification of endomesodermal territories in the sea urchin embryo depends on a moving torus of regulatory gene expression. We show how this dynamic patterning function is encoded in a gene regulatory network (GRN) subcircuit that includes the
otx, wnt8
, and
blimp1
genes, the cis-regulatory control systems of which have all been experimentally defined. A cis-regulatory reconstruction experiment revealed that
blimp1
autorepression accounts for progressive extinction of expression in the center of the torus, whereas its outward expansion follows reception of the Wnt8 ligand by adjacent cells. GRN circuitry thus controls not only static spatial assignment in development but also dynamic regulatory patterning.
Publisher
American Association for the Advancement of Science (AAAS)
Reference19 articles.
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