Prevention of Vaginal SHIV Transmission in Rhesus Macaques Through Inhibition of CCR5-Reference-Cited by-同舟云学术

Prevention of Vaginal SHIV Transmission in Rhesus Macaques Through Inhibition of CCR5

Published:2004-10-15 Issue:5695 Volume:306 Page:485-487
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Lederman Michael M.¹²³⁴⁵,Veazey Ronald S.¹²³⁴⁵,Offord Robin¹²³⁴⁵,Mosier Donald E.¹²³⁴⁵,Dufour Jason¹²³⁴⁵,Mefford Megan¹²³⁴⁵,Piatak Michael¹²³⁴⁵,Lifson Jeffrey D.¹²³⁴⁵,Salkowitz Janelle R.¹²³⁴⁵,Rodriguez Benigno¹²³⁴⁵,Blauvelt Andrew¹²³⁴⁵,Hartley Oliver¹²³⁴⁵

Affiliation:

1. Department of Medicine, Case Western Reserve University, University Hospitals, 2061 Cornell Road, Cleveland, OH 44106, USA.

2. Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA.

3. Department of Structural Biology and Bioinformatics, Faculty of Medicine, University of Geneva, 1211 Geneva 4, Switzerland.

4. Scripps Research Institute, 10550 Torrey Pines Road, La Jolla, CA 92037, USA.

5. AIDS Vaccine Program, SAIC Frederick, Inc., National Cancer Institute, Frederick, MD 21702-1201, USA.

Abstract

Topical agents, such as microbicides, that can protect against human immunodeficiency virus (HIV) transmission are urgently needed. Using a chimeric simian/human immunodeficiency virus (SHIV SF162), which is tropic for the chemokine receptor CCR5, we report that topical application of high doses of PSC-RANTES, an amino terminus–modified analog of the chemokine RANTES, provided potent protection against vaginal challenge in rhesus macaques. These experimental findings have potentially important implications for understanding vaginal transmission of HIV and the design of strategies for its prevention.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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