Melanopsin ( Opn4 ) Requirement for Normal Light-Induced Circadian Phase Shifting-Reference-Cited by-同舟云学术

Melanopsin ( Opn4 ) Requirement for Normal Light-Induced Circadian Phase Shifting

Published:2002-12-13 Issue:5601 Volume:298 Page:2213-2216
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Panda Satchidananda¹²,Sato Trey K.¹²,Castrucci Ana Maria³⁴,Rollag Mark D.³,DeGrip Willem J.⁵,Hogenesch John B.¹,Provencio Ignacio³,Kay Steve A.¹²

Affiliation:

1. Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Drive, San Diego, CA 92121, USA.

2. Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, San Diego, CA 92037, USA.

3. Department of Anatomy, Physiology, & Genetics, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD 20814, USA.

4. Department of Physiology, University of Saõ Paolo, Post Office Box 11176, Saõ Paolo 05422, Brazil.

5. Department of Biochemistry, University of Nijmegen, Post Office Box 9101, 6500 HB Nijmegen, The Netherlands.

Abstract

The master circadian oscillator in the hypothalamic suprachiasmatic nucleus is entrained to the day/night cycle by retinal photoreceptors. Melanopsin ( Opn4 ), an opsin-based photopigment, is a primary candidate for photoreceptor-mediated entrainment. To investigate the functional role of melanopsin in light resetting of the oscillator, we generated melanopsin-null mice ( Opn4 −/− ). These mice entrain to a light/dark cycle and do not exhibit any overt defect in circadian activity rhythms under constant darkness. However, they display severely attenuated phase resetting in response to brief pulses of monochromatic light, highlighting the critical role of melanopsin in circadian photoentrainment in mammals.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference29 articles.

1. Suppression of Melatonin Secretion in Some Blind Patients by Exposure to Bright Light

2. Regulation of Mammalian Circadian Behavior by Non-rod, Non-cone, Ocular Photoreceptors

3. Absence of extraocular photoreception in diurnal and nocturnal rodents exposed to direct sunlight

4. Circadian photoreception in the retinally degenerate mouse (rd/rd)

5. A Novel Human Opsin in the Inner Retina

Cited by 731 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Dynamic endocannabinoid-mediated neuromodulation of retinal circadian circuitry;Ageing Research Reviews;2024-08

2. Developmental control of rod number via a light-dependent retrograde pathway from intrinsically photosensitive retinal ganglion cells;Developmental Cell;2024-08

3. Striatal projection neurons coexpressing dopamine D1 and D2 receptors modulate the motor function of D1- and D2-SPNs;Nature Neuroscience;2024-07-04

4. Binocular combination in the autonomic nervous system;2024-06-05

5. Flp-recombinase mouse line for genetic manipulation of ipRGCs;2024-05-08