Pulmonary neuroendocrine cells amplify allergic asthma responses-Reference-Cited by-同舟云学术

Pulmonary neuroendocrine cells amplify allergic asthma responses

Published:2018-06-08 Issue:6393 Volume:360 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Sui Pengfei¹²^ORCID,Wiesner Darin L.³,Xu Jinhao¹²^ORCID,Zhang Yan¹²^ORCID,Lee Jinwoo⁴^ORCID,Van Dyken Steven⁴^ORCID,Lashua Amber²^ORCID,Yu Chuyue⁵^ORCID,Klein Bruce S.³^ORCID,Locksley Richard M.⁴^ORCID,Deutsch Gail⁶^ORCID,Sun Xin¹²^ORCID

Affiliation:

1. Department of Pediatrics, University of California, San Diego, San Diego, CA 92093, USA.

2. Laboratory of Genetics, University of Wisconsin–Madison, Madison, WI 53706, USA.

3. Department of Pediatrics, University of Wisconsin–Madison, Madison, WI 53706, USA.

4. Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA.

5. Zhiyuan College, Shanghai JiaoTong University, Shanghai, China.

6. Department of Laboratories, Seattle Children’s Hospital, University of Washington, Seattle, WA 98105, USA.

Abstract

Finding a role for PNECs in asthma Pulmonary neuroendocrine cells (PNECs) are a rare cell type located in airway and alveolar epithelia and are often in contact with sensory nerve fibers. They have a wide phylogenic distribution and are found even in the relatively primitive lungs of amphibia and reptiles, suggesting a critical function. Sui et al. found that mice lacking PNECs have suppressed type 2 (allergic) immune responses. PNECs were observed in close proximity to group 2 innate lymphoid cells (ILC2s) around airway branch points. The PNECs enhanced ILC2 activity by secreting CGRP (calcitonin gene-related peptide). They also induced goblet-cell hyperplasia via the neurotransmitter GABA (γ-aminobutyric acid). Interestingly, human asthma patients were found to have increased PNEC numbers, suggesting a potential therapeutic target for the treatment of asthma. Science , this issue p. eaan8546

Funder

National Institutes of Health

Wisconsin Partnership Program

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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