Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling

Author:

Schieber Alexandria M. Palaferri1,Lee Yujung Michelle1,Chang Max W.2,Leblanc Mathias3,Collins Brett3,Downes Michael3,Evans Ronald M.34,Ayres Janelle S.1

Affiliation:

1. Nomis Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

2. Integrative Genomics and Bioinformatics Core, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

3. Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

4. Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

Abstract

The benefits of Escherichia coli Infection and intestinal damage can trigger severe muscle wasting and loss of fat in mice. How this happens is poorly understood. Palaferri Schieber et al. discovered a protective Escherichia coli strain in their mouse colony. Mice intestinally colonized with the E. coli and infected with the food-poisoning bug Salmonella or with the lung pathogen Burkholderia did not waste away. Without the E. coli , similarly infected mice became fatally ill. The protective E. coli stimulated an innate immune mechanism that ensured that muscle-signaling pathways were not damaged by infection. Thus, the friendly E. coli allowed its host to tolerate and survive the pathogens. Science , this issue p. 558

Funder

NIH

Howard Hughes Medical Institute

Samuel Waxman Cancer Research Foundation

Leona M. and Harry B. Helmsley Charitable Trust

NOMIS Foundation

Searle Scholar Foundation

Ray Thomas Edward Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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