HCV Persistence and Immune Evasion in the Absence of Memory T Cell Help-Reference-Cited by-同舟云学术

HCV Persistence and Immune Evasion in the Absence of Memory T Cell Help

Published:2003-10-24 Issue:5645 Volume:302 Page:659-662
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Grakoui Arash¹²³⁴⁵,Shoukry Naglaa H.¹²³⁴⁵,Woollard David J.¹²³⁴⁵,Han Jin-Hwan¹²³⁴⁵,Hanson Holly L.¹²³⁴⁵,Ghrayeb John¹²³⁴⁵,Murthy Krishna K.¹²³⁴⁵,Rice Charles M.¹²³⁴⁵,Walker Christopher M.¹²³⁴⁵

Affiliation:

1. Center for the Study of Hepatitis C, Rockefeller University, New York, NY 10021, USA.

2. Center for Vaccines and Immunity, Columbus Children's Research Institute, 700 Children's Drive, W503, Columbus, OH 43205, USA.

3. Centocor, Malvern, PA 19355, USA.

4. Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA.

5. Department of Pediatrics, College of Medicine and Public Health, Ohio State University, Columbus, OH 43205, USA.

Abstract

Spontaneous resolution of hepatitis C virus (HCV) infection in humans usually affords long-term immunity to persistent viremia and associated liver diseases. Here, we report that memory CD4 + Tcells are essential for this protection. Antibody-mediated depletion of CD4 + Tcells before reinfection of two immune chimpanzees resulted in persistent, low-level viremia despite functional intra-hepatic memory CD8 + Tcell responses. Incomplete control of HCV replication by memory CD8 + Tcells in the absence of adequate CD4 + Tcell help was associated with emergence of viral escape mutations in class I major histocompatibility complex–restricted epitopes and failure to resolve HCV infection.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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