Affiliation:
1. Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA.
Abstract
Sleep is universal, strictly regulated, and necessary for cognition. Why this is so remains a mystery, although recent work suggests that sleep, memory, and plasticity are linked. However, little is known about how wakefulness and sleep affect synapses. Using Western blots and confocal microscopy in
Drosophila
, we found that protein levels of key components of central synapses were high after waking and low after sleep. These changes were related to behavioral state rather than time of day and occurred in all major areas of the
Drosophila
brain. The decrease of synaptic markers during sleep was progressive, and sleep was necessary for their decline. Thus, sleep may be involved in maintaining synaptic homeostasis altered by waking activities.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
285 articles.
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