Affiliation:
1. Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA.
Abstract
Our understanding of the genetic basis of phenotypic diversity is limited by the paucity of examples in which multiple, interacting loci have been identified. We show that natural variation in the efficiency of sporulation, the program in yeast that initiates the sexual phase of the life cycle, between oak tree and vineyard strains is due to allelic variation between four nucleotide changes in three transcription factors:
IME1, RME1
, and
RSF1
. Furthermore, we identified that selection has shaped quantitative variation in yeast sporulation between strains. These results illustrate how genetic interactions between transcription factors are a major source of phenotypic diversity within species.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
187 articles.
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