Regenerative potential of prostate luminal cells revealed by single-cell analysis-Reference-Cited by-同舟云学术

Regenerative potential of prostate luminal cells revealed by single-cell analysis

Published:2020-05 Issue:6490 Volume:368 Page:497-505
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Karthaus Wouter R.¹^ORCID,Hofree Matan²^ORCID,Choi Danielle¹^ORCID,Linton Eliot L.¹^ORCID,Turkekul Mesruh³^ORCID,Bejnood Alborz²^ORCID,Carver Brett¹,Gopalan Anuradha¹,Abida Wassim¹^ORCID,Laudone Vincent¹,Biton Moshe²^ORCID,Chaudhary Ojasvi⁴^ORCID,Xu Tianhao⁴^ORCID,Masilionis Ignas⁴^ORCID,Manova Katia³^ORCID,Mazutis Linas⁴^ORCID,Pe’er Dana⁴⁵,Regev Aviv²⁶⁷^ORCID,Sawyers Charles L.¹⁶^ORCID

Affiliation:

1. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

2. Klarman Cell Observatory, Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.

3. Molecular Cytology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

4. Program for Computational and Systems Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

5. Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

6. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

7. Koch Institute of Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Abstract

Equal opportunity tissue regeneration Tissue regeneration is thought to be driven primarily by rare stem cells with distinctive properties. Single-cell RNA sequencing allows rigorous testing of this hypothesis. Karthaus et al. examined the regeneration of normal prostate tissue in mice after androgen ablation, a common treatment for prostate cancer (see the Perspective by Kelly). Unexpectedly, they found that in addition to rare stem cells, a large population of differentiated cells was a major contributor to prostate regeneration, a result that they confirmed in a study of human prostate tissue. Investigation of the molecular mechanism by which the differentiated cells acquired regenerative potential yielded insights that could potentially lead to improved therapies for prostate cancer. Science , this issue p. 497 ; see also p. 467

Funder

Howard Hughes Medical Institute

National Cancer Institute

Starr Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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