Thymine Dimerization in DNA Is an Ultrafast Photoreaction-Reference-Cited by-同舟云学术

Thymine Dimerization in DNA Is an Ultrafast Photoreaction

Published:2007-02-02 Issue:5812 Volume:315 Page:625-629
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Schreier Wolfgang J.¹²³,Schrader Tobias E.¹²³,Koller Florian O.¹²³,Gilch Peter¹²³,Crespo-Hernández Carlos E.¹²³,Swaminathan Vijay N.¹²³,Carell Thomas¹²³,Zinth Wolfgang¹²³,Kohler Bern¹²³

Affiliation:

1. Department für Physik, Ludwig-Maximilians-Universität, Oettingenstrasse 67, D-80538 München, Germany.

2. Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, OH 43210, USA.

3. Fakultät für Chemie und Pharmazie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, D-81377 München, Germany.

Abstract

Femtosecond time-resolved infrared spectroscopy was used to study the formation of cyclobutane dimers in the all-thymine oligodeoxynucleotide (dT) 18 by ultraviolet light at 272 nanometers. The appearance of marker bands in the time-resolved spectra indicates that the dimers are fully formed ∼1 picosecond after ultraviolet excitation. The ultrafast appearance of this mutagenic photolesion points to an excited-state reaction that is approximately barrierless for bases that are properly oriented at the instant of light absorption. The low quantum yield of this photoreaction is proposed to result from infrequent conformational states in the unexcited polymer, revealing a strong link between conformation before light absorption and photodamage.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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