Estimation of Epidemic Size and Incubation Time Based on Age Characteristics of vCJD in the United Kingdom-Reference-Cited by-同舟云学术

Estimation of Epidemic Size and Incubation Time Based on Age Characteristics of vCJD in the United Kingdom

Published:2001-11-23 Issue:5547 Volume:294 Page:1726-1728
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Valleron Alain-Jacques¹,Boelle Pierre-Yves¹,Will Robert²,Cesbron Jean-Yves³

Affiliation:

1. Epidemiology and Information Sciences, INSERM U444, CHU Saint-Antoine, Université Pierre et Marie Curie et Assistance Publique–Hôpitaux de Paris, 27 rue Chaligny, 75012 Paris, France.

2. National Creutzfeldt-Jakob Disease Surveillance Unit, Western General Hospital, Edinburgh EH4 2XU, UK.

3. Immunité Anti-Infectieuse JE 2236, UFR de Médecine de Grenoble, Université Joseph Fourier, Domaine de la Merci, 38706 La Tronche, France.

Abstract

The size of the variant Creutzfeldt-Jakob Disease (vCJD) epidemic in the United Kingdom is a major public health concern and a subject of speculation. The cases are young (mean age = 28). Assuming that the risk of developing the disease in susceptible exposed subjects decreases exponentially with age after age 15, that all infections occurred between 1980 and 1989, and that the distribution of the incubation period is lognormal, we estimate that the mean duration of the incubation period is 16.7 years [95% confidence interval (CI): 12.4 to 23.2] and that the total number of cases will be 205 (upper limit of the 95% CI: 403).

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference18 articles.

1. Transmissions to mice indicate that ‘new variant’ CJD is caused by the BSE agent

2. N. M. Ferguson C. A. Donnelly M. E. J. Woolhouse R. M. Anderson Philos. Trans. R. Soc. London Ser. B Biol. Sci. 352 803 (1997).

3. When did bovine spongiform encephalopathy (BSE) start? Implications on the prediction of a new variant of Creutzfeldt-Jakob disease (nvCJD) epidemic

4. “Opinion of the scientific steering committee on the human exposure risk (HER) via food with respect to BSE” (European Union Scientific Steering Committee 10 December 1999)

5. Predicting the CJD epidemic in humans

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