Synergy Between Tumor Suppressor APC and the β-Catenin-Tcf4 Target Tcf1
Author:
Affiliation:
1. Department of Immunology and
2. Department of Pathology, University Medical Center Utrecht, Post Office Box 85500, 3508 GA Utrecht, Netherlands.
3. Center for Biomedical Genetics,
Abstract
Publisher
American Association for the Advancement of Science (AAAS)
Subject
Multidisciplinary
Reference54 articles.
1. About 50% of the Western population develop colorectal adenomas by the age of 70 [
2. Ransohoff D., Lang C., N. Engl. J. Med. 325, 37 (1991);
3. ] and at least 85% of these tumors contain APC mutations [
4. Miyoshi Y., et al., Hum. Mol. Genet. 1, 229 (1992);
5. Jen J., et al., Cancer Res. 54, 5523 (1994);
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